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中华胸部外科电子杂志 ›› 2018, Vol. 05 ›› Issue (03) : 184 -188. doi: 10.3877/cma.j.issn.2095-8773.2018.03.09

所属专题: 文献

综述

表皮生长因子受体酪氨酸激酶抑制剂与非小细胞肺癌的临床研究现状
续文栋1, 吕朋1, 李健1, 王昊1, 马金山2,()   
  1. 1. 300300 天津医科大学总医院空港医院胸外科
    2. 830049 乌鲁木齐,新疆维吾尔自治区胸科医院胸外科
  • 收稿日期:2018-01-09 出版日期:2018-08-28
  • 通信作者: 马金山
  • 基金资助:
    新疆维吾尔自治区自然科学基金(2015211C193)

Current status of clinical research on EGFR-TKI and non-small cell lung cancer

Wendong Xu1, Peng Lyu1, Jian Li1, Hao Wang1, Jinshan Ma2,()   

  1. 1. Department of Thoracic Surgery, Tianjin Medical University General Hospital Airport Hospital, Tianjin 300300, China
    2. Department of Thoracic Surgery, Xinjiang Uygur Autonomous Region Chest Hospital, Urumchi 830049, China
  • Received:2018-01-09 Published:2018-08-28
  • Corresponding author: Jinshan Ma
  • About author:
    Corresponding author: Ma Jinshan, Email:
引用本文:

续文栋, 吕朋, 李健, 王昊, 马金山. 表皮生长因子受体酪氨酸激酶抑制剂与非小细胞肺癌的临床研究现状[J/OL]. 中华胸部外科电子杂志, 2018, 05(03): 184-188.

Wendong Xu, Peng Lyu, Jian Li, Hao Wang, Jinshan Ma. Current status of clinical research on EGFR-TKI and non-small cell lung cancer[J/OL]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2018, 05(03): 184-188.

表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)能显著改善EGFR激活突变的晚期非小细胞肺癌(NSCLC)患者的生存期。几乎所有EGFR突变的NSCLC肿瘤最终都获得了对EGFR-TKIs的耐药性,而获得EGFR-TKIs耐药性是目前治疗EGFR突变的NSCLC面临的巨大挑战。近几年来,在EGFR-TKI药物的研究及NSCLC的治疗方面有了新的突破,该文就EGFR-TKI与NSCLC的相关临床研究及应用取得的进展进行阐述。

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can significantly improve the survival rate of patients who suffered terminal non-small cell lung cancer (NSCLC) with EGFR activating mutations. Almost all NSCLS with EGFR mutations eventually acquire resistance to EGFR-TKIs, which is a huge challenge on effective treatments. In recent years, there have been new breakthroughs in the research of EGFR-TKI and the treatment of NSCLC. This article describes the recent progresses in the clinical research and application of EGFR-TKI and NSCLC.

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