| 1 | 
																						 
											  Liebermann MD, Allgower M, Schmid P, et al. Muscular equivalent of the lower esophageal sphincter[J]. Gastroenterology, 1979, 76(1):31-38. 
											 											 | 
										
																													
																						| 2 | 
																						 
											  Yanfen J, Valmik B, Ravinder KM. Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter[J]. Am J Physiol Gastrointest Liver Physiol, 2009, 297(2):G397-G405. 
											 											 | 
										
																													
																						| 3 | 
																						 
											  Hornby PJ, Abrahams TP. Central control of lower esophageal sphincter relaxation[J]. Am J Med, 2000, 108(Suppl 4a):90S-98S. 
											 											 | 
										
																													
																						| 4 | 
																						 
											  Chang HY, Mashimo H, Goyal RK. Musings on the Wanderer: What's New in Our Understanding of Vago-Vagal Reflex? : Ⅳ. Current concepts of vagal efferent projections to the gut[J]. Am J Physiol Gastrointest Liver Physiol, 2003, 284(3):G357-G366 
											 											 | 
										
																													
																						| 5 | 
																						 
											  Reynolds JC, Ouyang A, Cohen S. A lower esophageal sphincter reflex involving substance P[J]. Am J Physiol, 1984,246(4 Pt 1):G346-G354. 
											 											 | 
										
																													
																						| 6 | 
																						 
											  Rattan S, Fan YP, Chakder S. Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin Ⅸ[J]. Am J Physiol. 1999,276(1 Pt 1):G138-G145. 
											 											 | 
										
																													
																						| 7 | 
																						 
											  温士旺,刘俊峰,高立平. 一氧化氮介导的人食管下括约肌舒张的作用机制[J]. 中华医学杂志,2006, 86(1):31-34. 
											 											 | 
										
																													
																						| 8 | 
																						 
											  Jensen SL, Aggestrup S, Fahrenkrug J, et al. Electric stimulation of the autonomic nervous system and vasoactive intestinal peptide and substance P release on the lower esophageal sphincter[J]. Acta Gastroenterol Latinoam, 1990, 20(3):131-136.JP 
											 											 | 
										
																													
																						| 9 | 
																						 
											  Liu JF, Sun J, Drew PA. Characterization of excitatory and inhibitory motor neurons to the human gastric clasp and sling fibers[J]. Can J Physiol Pharmacol, 2011, 89(9):617-622. 
											 											 | 
										
																													
																						| 10 | 
																						 
											  Paterson WG, Anderson MA, Anand N. Pharmacological characterization of lower esophageal sphincter relaxation induced by swallowing, vagal efferent nerve stimulation, and esophageal distention[J]. Can J Physiol Pharmacol, 1992, 70(7):1011-1015. 
											 											 | 
										
																													
																						| 11 | 
																						 
											  Tomita R, Tanjoh K, Munakata K. The role of motilin and cisapride in the enteric nervous system of the lower esophageal sphincter in humans[J]. Surg Today, 1997, 27(11):985-992. 
											 											 | 
										
																													
																						| 12 | 
																						 
											  Yuan S, Costa, Brookes SJ. Neuronal pathways and transmission to the lower esophageal sphincter of the guinea pig[J]. Gastroenterology, 1998, 115(3):661-671. 
											 											 | 
										
																													
																						| 13 | 
																						 
											  Behar J, Kerstein M, Biancani P. Neural control of the lower esophageal sphincter in the cat: studies on the excitatory pathways to the lower esophageal sphincter[J]. Gastroenterology, 1982, 82(4):680-688. 
											 											 | 
										
																													
																						| 14 | 
																						 
											  Liu JF, Lu HL, Wen SW, et al. Effects of acetylcholine on sling and clasp fibers of the human lower esophageal sphincter[J]. J Gastroenterol Hepatol, 2011, 26(8):1309-1317. 
											 											 | 
										
																													
																						| 15 | 
																						 
											  Brookes SJ, Chen BN, Hodgson WM, et al. Characterization of excitatory and inhibitory motor neurons to the guinea pig lower esophageal sphincter[J]. Gastroenterology, 1996, 111(1):108-117. 
											 											 | 
										
																													
																						| 16 | 
																						 
											  Asensio A, Gonza′lez, Ricard F, et al. Different responsiveness of excitatory and inhibitory enteric motor neurons in the human esophagus to electrical field stimulation and to nicotine[J]. Am J Physiol, 2004, 287(1):G299-G306. 
											 											 | 
										
																													
																						| 17 | 
																						 
											  Murray J, Ledlow A, Launspach J, et al. The effects of recombinant human hemoglobin on Forman esophageal motor function in humans[J]. Gastroenterology, 1995, 109(4):1241-1248. 
											 											 | 
										
																													
																						| 18 | 
																						 
											  Daniel E, Helmy-Elkholy A, Jager L, et al. Neither purine nor VIP is the mediator of inhibitory nerves of opossum esophageal smooth muscle[J]. J Physiol, 1983, 336(3):243-260. 
											 											 | 
										
																													
																						| 19 | 
																						 
											  Conklin JL, Murray JA, Ledlow A, et al. Effects of recombinant human hemoglobin on opossum esophageal motor function[J]. J Pharmacol Exp Ther, 1995, 273(2):762-767. 
											 											 | 
										
																													
																						| 20 | 
																						 
											  Murray JA, Ledlow A, Launspach J, et al. The effects of recombinant human hemoglobin on esophageal motor functions in humans[J]. Gastroenterology, 1995, 109(4):1241-1248. 
											 											 | 
										
																													
																						| 21 | 
																						 
											  Uc A, Oh ST, Murray JA, et al. Biphasic relaxation of the opossum lower esophageal sphincter: roles of NO, VIP, and CGRP[J]. Am J Physiol, 1999, 277(3 Pt 1):G548-554. 
											 											 | 
										
																													
																						| 22 | 
																						 
											  Li HF, Liu JF, Zhang K, et al. Expression of serotonin receptors in human lower esophageal sphincter[J]. Exp Ther Med, 2015, 9(1):49-54. 
											 											 | 
										
																													
																						| 23 | 
																						 
											  Tian ZQ, Liu JF, Wang GY, et al. Responses of human clasp and sling fibers to neuromimetics[J]. J Gastroenterol Hepatol, 2004, 19(4):440-447. 
											 											 | 
										
																													
																						| 24 | 
																						 
											  Sigala S, Missale G, Raddino R, et al. Opposing roles for D-1 and D-2 dopamine receptors in the regulation of lower esophageal sphincter motility in the rat[J]. Life sciences, 1994, 54(15):1035-1045. 
											 											 | 
										
																													
																						| 25 | 
																						 
											  Liu XB, Liu JF. Expression of dopamine receptors in human lower esophageal sphincter[J]. J Gastroenterol Hepatol, 2012, 27(5):945-950. 
											 											 | 
										
																													
																						| 26 | 
																						 
											  Sandler AD, Maher JW, Weinstock JV, et al. Tachykinins in the canine gastroesophageal junction[J]. Am J Surg,1991, 161(1):165-170. 
											 											 | 
										
																													
																						| 27 | 
																						 
											  Zhang K, Chen QT, Li JH, et al. The expression of tachykinin receptors in the human lower esophageal sphincter[J]. Eur J Pharmacol, 2016(774):144-149. 
											 											 | 
										
																													
																						| 28 | 
																						 
											  真岩波,张淑红,孙晓辉.反流性食管炎患者血浆胃动素、胃排空时间相关性研究[J].临床荟萃,2003,18(20):1149-1150. 
											 											 | 
										
																													
																						| 29 | 
																						 
											  Perdikis G, Wilson P, Hinder RA,et al. Gastroesophageal reflux disease is associated with enteric hormone abnormalities[J]. Am J Surg 1994, 167(1):186-191; discussion. 
											 											 | 
										
																													
																						| 30 | 
																						 
											  高立平,刘俊峰,温士旺,等. 胃泌素和胃动素对人离体食管下括约肌张力的调节机制[J]. 基础医学与临床,2006, 26(3):257-260. 
											 											 | 
										
																													
																						| 31 | 
																						 
											  Nelson J, Bagnato A, Battistini B, et al. The endothelin axis: emerging role in cancer[J]. Nat Rev Cancer, 2003, 3(2):110-116. 
											 											 | 
										
																													
																						| 32 | 
																						 
											  Mittal RK, McCallum RW. Characteristics of transient lower esophageal sphincter relaxation in humans[J]. Am J Physiol Gastrointest Liver Physiol, 1987, 252(5 Pt 1):G636-G641. 
											 											 | 
										
																													
																						| 33 | 
																						 
											  Farré R, Sifrim D. Regulation of basal tone, relaxation and contraction of the lower oesophageal sphincter. Relevance to drug discovery for oesophageal disorders[J]. Br J Pharmacol, 2008, 153(5):858-869. 
											 											 | 
										
																													
																						| 34 | 
																						 
											  Liu JF, Zhang J, Liu XB, et al. Investigation of cholecystokinin receptors in the human lower esophageal sphincter[J]. World J Gastroenterol, 2014, 20(21):6554-6559. 
											 											 | 
										
																													
																						| 35 | 
																						 
											  Masclee AA, Lam WF, Lamers CB. Effect of bombesin on esophageal motility in humans[J]. Dis Esophagus, 1999, 12(1):54-59. 
											 											 | 
										
																													
																						| 36 | 
																						 
											  Feng Y, Liu JF. Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter[J]. Exp Ther Med, 2014, 7(2):423-428. 
											 											 | 
										
																													
																						| 37 | 
																						 
											  Tao J, Liu JF. Expression of β-adrenoceptors in human lower esophageal sphincter[J]. Hepatogastroenterology, 2013, 60(122):324-327. 
											 											 |