人食管下括约肌收缩和舒张调节机制的研究进展

doi:10.3877/cma.j.issn.2095-8773.2018.04.08

中华胸部外科电子杂志 ›› 2018, Vol. 05 ›› Issue (04) : 239 -242. doi: 10.3877/cma.j.issn.2095-8773.2018.04.08

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人食管下括约肌收缩和舒张调节机制的研究进展

张珂¹^,^†(

), 薛金伟², 黄峻岭³, 刘杰⁴, 刘海彬⁵, 宋莲莲⁶

^1. 071000　保定，河北大学附属医院胸外科
^2. 071000　保定，河北大学附属医院骨外科
^3. 071400　保定市蠡县医院胸外科
^4. 071400　保定市蠡县医院神经外科
^5. 0711006　保定市清苑区人民医院普通外科
^6. 071400　保定市蠡县医院手术室

收稿日期:2018-08-25 出版日期:2018-11-28
通信作者: 张珂
基金资助:
国家自然科学基金项目(30371413)

Recent research advances in the mechanism of contraction and diastolic regulation of human lower esophageal sphincter

Ke Zhang¹^,^†(), Jinwei Xue², Junling Huang³, Jie Liu⁴, Haibin Liu⁵, Lianlian Song⁶

^1. Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000
^2. Department of Orthopeadic Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000
^3. Department of Thoracic Surgery, Hospital of Lixian County, Baoding, Hebei Province 071400
^4. Department of Neurosurgery, Hospital of Lixian County, Baoding, Hebei Province 071400
^5. Department of General Surgery, The People’s Hospital of Qingyuan District of Baoding City, Hebei Province 071100
^6. Department of Operation Room, Hospital of Lixian County, Baoding, Hebei Province 071400

Received:2018-08-25 Published:2018-11-28
Corresponding author: Ke Zhang
About author:
Corresponding author: Zhang Ke, Email: tumor@vip.qq.com

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引用本文：

张珂, 薛金伟, 黄峻岭, 刘杰, 刘海彬, 宋莲莲. 人食管下括约肌收缩和舒张调节机制的研究进展[J]. 中华胸部外科电子杂志, 2018, 05(04): 239-242.

Ke Zhang, Jinwei Xue, Junling Huang, Jie Liu, Haibin Liu, Lianlian Song. Recent research advances in the mechanism of contraction and diastolic regulation of human lower esophageal sphincter[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2018, 05(04): 239-242.

人食管下括约肌(LES)包括神经调节、自身调节、体液调节三种调节方式。三种方式中神经调节虽然通过多种不同的神经递质完成，但其最终也是由控制自身调节机制的肌间神经丛来完成调节功能。体液调节涉及多种激素类物质，主要的激素类物质因配体和受体的不同调节功能也不尽相同。有些激素类物质对人LES的调节作用机制还需要进一步研究。

关键词: 食管下括约肌，人, 神经调节, 自身调节, 体液调节

Human lower esophageal sphincter (LES) is regulated by neuroregulation, self-regulation and humoral regulation. Although neuroregulation is accomplished by a variety of different neurotransmitters, it is ultimately accomplished by the myenteric plexus that controls the self-regulation mechanism. Humoral regulation involves a variety of hormone substances, and the main hormone substances have different regulatory functions due to different ligands and receptors. The regulatory mechanism of some hormones on human LES needs further study.

Key words: Lower esophageal sphincter, Human, Neuroregulation, Self-regulation, Humoral regulation

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