切换至 "中华医学电子期刊资源库"

中华胸部外科电子杂志 ›› 2021, Vol. 08 ›› Issue (02) : 108 -112. doi: 10.3877/cma.j.issn.2095-8773.2021.02.06

所属专题: 文献

综述

多发肺结节的外科治疗进展
王芝馀1, 陶润仪1, 冯锦腾1, 范坤1, 王泓懿1, 赵恒1, 刘博豪1, 李益行1, 张言鹏1, 张佳1, 张广健1, 付军科1,()   
  1. 1. 710061 西安,西安交通大学第一附属医院胸外科
  • 收稿日期:2021-01-29 修回日期:2021-03-19 接受日期:2021-03-29 出版日期:2021-05-28
  • 通信作者: 付军科
  • 基金资助:
    陕西省重点研发计划(2018SF-022); 陕西省重点研发计划(2021SF-034)

Progress in surgical treatment of multiple pulmonary nodules

Zhiyu Wang1, Runyi Tao1, Jinteng Feng1, Kun Fan1, Hongyi Wang1, Heng Zhao1, Bohao Liu1, Yixing Li1, Yanpeng Zhang1, Jia Zhang1, Guangjian Zhang1, Junke Fu1,()   

  1. 1. Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
  • Received:2021-01-29 Revised:2021-03-19 Accepted:2021-03-29 Published:2021-05-28
  • Corresponding author: Junke Fu
引用本文:

王芝馀, 陶润仪, 冯锦腾, 范坤, 王泓懿, 赵恒, 刘博豪, 李益行, 张言鹏, 张佳, 张广健, 付军科. 多发肺结节的外科治疗进展[J]. 中华胸部外科电子杂志, 2021, 08(02): 108-112.

Zhiyu Wang, Runyi Tao, Jinteng Feng, Kun Fan, Hongyi Wang, Heng Zhao, Bohao Liu, Yixing Li, Yanpeng Zhang, Jia Zhang, Guangjian Zhang, Junke Fu. Progress in surgical treatment of multiple pulmonary nodules[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2021, 08(02): 108-112.

随着科学技术的发展及肺癌筛查的普及,肺结节的发现率逐渐升高,而其中许多患者存在肺内多发结节。在很多情况下,仅靠影像学检查是不能明确诊断的,这时就需要外科介入来进行诊断及治疗。然而,当前对于多发肺结节的外科治疗尚没有明确统一的指南指导,特别是对于亚厘米纯磨玻璃结节以及主病灶切除后余下结节的处理仍具有争议。

With the development of science and technology as well as the popularization of lung cancer screening, the discovery rate of pulmonary nodules has gradually increased, many of which are multiple pulmonary nodules. In many cases, the diagnosis cannot be confirmed only by radiologic appearance, where surgical intervention is required for diagnosis and treatment. However, currently there are no clear and unified guidelines for the surgical treatment of multiple pulmonary nodules, especially for the treatment of sub-centimeter pure ground-glass nodules and the remaining nodules after resection of the primary lesions. This article collects and summarizes the treatment of multiple pulmonary nodules mentioned in several guidelines.

1
Lim HJ, Ahn S, Lee KS,et al.Persistent pure ground-glass opacity lung nodules ≥ 10 mm in diameter at CT scan: histopathologic comparisons and prognostic implications[J].Chest,2013,144(4):1291-1299.
2.
Heuvelmans MA, Walter JE, Peters RB,et al.Relationship between nodule count and lung cancer probability in baseline CT lung cancer screening:The NELSON study[J].Lung Cancer,2017,113:45-50.
3.
吴雪杰,陈东来,朱蓉英,等.多发肺结节的基础研究和临床治疗进展[J].中国肺癌杂志,2019,22(3):173-177.
4.
周清华,范亚光,王颖,等.中国肺部结节分类、诊断与治疗指南(2016年版)[J].中国肺癌杂志,2016,19(12):793-798.
5.
MacMahon H, Naidich DP, Goo JM,et al.Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017[J].Radiology,2017,284(1):228-243.
6.
Ghosh S, Mehta AC, Abuquyyas S,et al.Primary lung neoplasms presenting as multiple synchronous lung nodules[J].Eur Respir Rev,2020,29(157):190142.
7.
Liu M, He WX, Song N,et al.Discrepancy of epidermal growth factor receptor mutation in lung adenocarcinoma presenting as multiple ground-glass opacities[J].Eur J Cardiothorac Surg,2016,50(5):909-913.
8.
Yu YC, Hsu PK, Yeh YC,et al.Surgical results of synchronous multiple primary lung cancers: similar to the stage-matched solitary primary lung cancers?[J].Ann Thorac Surg,2013,96(6):1966-1974.
9.
Gould MK, Donington J, Lynch WR,et al.Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer,3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines[J].Chest,2013,143(5 Suppl):e93S-e120S.
10.
Bai C, Choi CM, Chu CM,et al.Evaluation of Pulmonary Nodules: Clinical Practice Consensus Guidelines for Asia[J].Chest,2016,150(4):877-893.
11.
张晓菊,白莉,金发光,等.肺结节诊治中国专家共识(2018年版)[J].中华结核和呼吸杂志,2018,41(10):763-771.
12.
姜格宁,陈昶,朱余明,等.上海市肺科医院磨玻璃结节早期肺腺癌的诊疗共识(第一版)[J].中国肺癌杂志,2018,21(3):147-159.
13.
钟文昭.肺癌多学科团队诊疗中国专家共识[J].中华肿瘤杂志,2020,42(10):817-828.
14.
Liu C, Zhao L, Wu F,et al.The multidisciplinary team plays an important role in the prediction of small solitary pulmonary nodules: a propensity-score-matching study[J].Ann Transl Med,2019,7(23):740.
15.
Ung KA, Campbell BA, Duplan D,et al.Impact of the lung oncology multidisciplinary team meetings on the management of patients with cancer[J].Asia Pac J Clin Oncol,2016,12(2):e298-e304.
16.
Chen K, Nie Y, Park S,et al.Development and Validation of Machine Learning-based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts[J].Clin Cancer Res,2021,27(8):2255-2265.
17.
Baldwin DR, Gustafson J, Pickup L,et al.External validation of a convolutional neural network artificial intelligence tool to predict malignancy in pulmonary nodules[J].Thorax,2020,75(4):306-312.
18.
刘丹,黄燕,周清华,等.肺结节/肺癌患者全程管理模式的设计与应用[J].中国肺癌杂志,2020,23(5):299-305.
19.
Zhang B, Zhu F, Ma X,et al.Matched-pair comparisons of stereotactic body radiotherapy (SBRT) versus surgery for the treatment of early stage non-small cell lung cancer: a systematic review and meta-analysis[J].Radiother Oncol,2014,112(2):250-255.
20.
Chua GWY, Chua KLM.Which patients benefit most from stereotactic body radiotherapy or surgery in medically operable non-small cell lung cancer? An in-depth look at patient characteristics on both sides of the debate[J].Thorac Cancer,2019,10(10):1857-1867.
21.
陈建华,喻珣.晚期非小细胞肺癌组织与血浆EGFR基因表达差异及临床意义[J].医学临床研究,2016,33(8):1463-1465.
22.
Chen C, Huang X, Yin W,et al.Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules[J].Clin Epigenetics,2020,12(1):39.
23.
Wu J, Shen Z.Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer[J].Cancer Med,2020,9(19):6909-6922.
[1] 彭旭, 邵永孚, 李铎, 邹瑞, 邢贞明. 结肠肝曲癌的诊断和外科治疗[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 108-110.
[2] 梁开地, 缑文斌, 莫居容. 肺癌组织中细胞角蛋白18的表达及与预后的相关性[J]. 中华肺部疾病杂志(电子版), 2023, 16(05): 688-690.
[3] 黄承路, 廖飞, 刘显平, 王志强. 血清外泌体Has_circ_0060937过度表达与NSCLC转移和不良预后的关系[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 490-494.
[4] 陈坤, 何傅梅, 方婷, 陈文瑞. 血清sCD73与EGFR/ALK野生型非小细胞肺癌免疫治疗效果的相关性分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 504-507.
[5] 朱超男, 王帅, 王文博, 郑贸根, 程远, 陈志全. 非小细胞肺癌患者组织miR-31-5p表达与临床病理特征及预后的关系[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 508-510.
[6] 徐天亮, 程干思, 吴亚平, 龚荣, 胡洁, 段群娣, 李承慧. 奥希替尼联合安罗替尼二线治疗转移性NSCLC的疗效分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 520-522.
[7] 赵超, 张乾. SAPB和TPVB在腔镜下肺癌根治术中的应用及镇痛效果分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 535-537.
[8] 蒙姣姣, 胡刚, 欧阳涣堃. 肺癌术前淋巴结转移及MWA手术效果预测分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 547-549.
[9] 魏婷婷, 胡小红, 龚自强, 熊鹿. 老年非小细胞肺癌组织ARPC2表达及与预后关系[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 584-586.
[10] 杜静怡, 徐兴祥. 循环肿瘤细胞在非小细胞肺癌中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 596-600.
[11] 师佩, 邱璐, 魏东东, 金发光, 顾兴. 光动力治疗肺癌患者的临床管理及预后分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 427-428.
[12] 宁晓矿, 郝普明, 闫睿, 刘云泽, 李宬润. 单向式三孔胸腔镜肺叶切除术治疗早期肺癌应用研究[J]. 中华腔镜外科杂志(电子版), 2023, 16(04): 227-232.
[13] 陈立如, 刘亮, 彭雷, 徐全, 章晔. 单孔胸腔镜左肺下叶袖式切除术:新辅助免疫化疗后手术[J]. 中华胸部外科电子杂志, 2023, 10(04): 228-233.
[14] 熊亚琼, 田文泽, 冷雪春, 尤振兵, 韦欣琪. 集束化干预在肺癌术后顽固性咳嗽中的应用[J]. 中华胸部外科电子杂志, 2023, 10(04): 207-212.
[15] 宋左东, 成兴华. 单孔胸腔镜下右上肺袖状切除术[J]. 中华胸部外科电子杂志, 2023, 10(03): 180-182.
阅读次数
全文


摘要