切换至 "中华医学电子期刊资源库"

中华胸部外科电子杂志 ›› 2016, Vol. 03 ›› Issue (04) : 239 -242. doi: 10.3877/cma.j.issn.2095-8773.2016.04.010

所属专题: 文献

综述

非小细胞肺癌肿瘤组织血管浸润对预后的影响
温焕舜1, 梁朝阳1,()   
  1. 1. 100029 北京,卫计委中日友好医院胸外科
  • 收稿日期:2016-03-20 出版日期:2016-11-28
  • 通信作者: 梁朝阳

Impact of blood vessel invasion on prognosis of non-small cell lung cancer

Huanshun Wen1, Chaoyang Liang1,()   

  1. 1. Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2016-03-20 Published:2016-11-28
  • Corresponding author: Chaoyang Liang
  • About author:
    Corresponding author: Chaoyang Liang, Email:
引用本文:

温焕舜, 梁朝阳. 非小细胞肺癌肿瘤组织血管浸润对预后的影响[J]. 中华胸部外科电子杂志, 2016, 03(04): 239-242.

Huanshun Wen, Chaoyang Liang. Impact of blood vessel invasion on prognosis of non-small cell lung cancer[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2016, 03(04): 239-242.

目前肺癌已成为我国发病率和病死率均位居第一的癌症,对于其预后相关因素的研究至关重要。TNM分期是评估肺癌预后最重要的指标,但相同分期的肺癌尤其是早期肺癌的预后仍然存在诸多变化。血管浸润在癌症的进展和转移上扮演重要角色,也可能成为非小细胞肺癌的预后因素。研究表明血管浸润对于早期肺癌尤其是未出现淋巴结转移的早期肺癌的预后有重要影响,有的学者进一步建议将血管浸润纳入早期肺癌的TNM分期系统。文章主要对血管浸润与非小细胞肺癌的预后进行了综述。

It is important to evaluate the prognostic factors for lung cancer which heads the incidence and mortality among cancers in China. TNM staging is a most important prognostic factor for lung cancer, but there are various outcomes for those with same TNM staging, especially in early lung cancer. Blood vessel invasion plays an important role in the progression and metastasis of cancer, and may be a prognostic factor for non-small cell lung cancer. Researches have indicated that blood vessel invasion has important impact on the prognosis of early lung cancer, especially for those without lymph node metastasis. Some scholars have also suggested that blood vessel invasion be involved in TNM staging system of early lung cancer. This review introduces the relationship between blood vessel invasion and outcomes in patients with non-small cell lung cancer.

[1]
Panel NSCLCPG. NCCN clinical practice guidelines in oncology: Non-Small Cell Lung Cancer[S]. Vesion 1, 2013.
[2]
YoshidaT,ShirakusaT,ShigematsuN, et al. Histopathological factors predictive for prognosis of lung cancer[J]. Jpn J Surg, 1979,9(3):210-217.
[3]
LiottaLA,KleinermanJ,SaidelGM, et al. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation[J]. Cancer Res, 1974 ,34(5):997-1004.
[4]
MacchiariniP,DulmetE,De MontprevilleV, et al. Prognostic significance of peritumoural blood and lymphatic vessel invasion by tumour cells in T4 non-small cell lung cancer following induction therapy[J]. Surg Oncol, 1995,4(2):91-99.
[5]
TsuchiyaT,AkamineS,MuraokaM, et al. Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy[J]. Lung Cancer, 2007,56(3):341-348.
[6]
BrechotJM,ChevretS,CharpentierMC, et al. Blood vessel and lymphatic vessel invasion in resected nonsmall cell lung carcinoma. Correlation with TNM stage and disease free and overall survival[J]. Cancer, 1996 ,78(10):2111-2118.
[7]
KesslerR,GasserB,MassardG, et al. Blood vessel invasion is a major prognostic factor in resected non-small cell lung cancer[J]. Ann Thorac Surg, 1996,62(5):1489-1493.
[8]
HashizumeS,NagayasuT,HayashiT, et al. Accuracy and prognostic impact of a vessel invasion grading system for stage IA non-small cell lung cancer[J]. Lung Cancer, 2009,65(3):363-370.
[9]
HoM,YangE,MatcukG, et al. Identification of endothelial cell genes by combined database mining and microarray analysis[J].Physiol Genomics, 2003,13(3):249-262.
[10]
RigauV,MolinaTJ,ChaffaudC, et al. Blood vessel invasion in resected non small cell lung carcinomas is predictive of metastatic occurrence[J]. Lung Cancer,2002,38(2):169-176.
[11]
MineoTC,AmbrogiV,BaldiA, et al. Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer[J]. J Clin Pathol,2004,57(6):591-597.
[12]
KhanOA,FitzgeraldJJ,FieldML, et al. Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung[J]. Ann Thorac Surg, 2004,77(4):1173-1178.
[13]
PonceletAJ,CornetJ,CoulonC, et al. Intra-tumoral vascular or perineural invasion as prognostic factors for long-term survival in early stage non-small cell lung carcinoma[J]. Eur J Cardiothorac Surg, 2008,33(5):799-804.
[14]
GaborS,RennerH,PopperH, et al. Invasion of blood vessels as significant prognostic factor in radically resected T1-3N0M0 non-small-cell lung cancer[J]. Eur J Cardiothorac Surg, 2004,25(3):439-442.
[15]
PechetTT,CarrSR,CollinsJE, et al. Arterial invasion predicts early mortality in stage I non-small cell lung cancer[J]. Ann Thorac Surg, 2004,78(5):1748-1753.
[16]
MiyoshiK,MoriyamaS,KunitomoT, et al. Prognostic impact of intratumoral vessel invasion in completely resected pathologic stage I non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2009,137(2):429-434.
[17]
Panel NSCLCPG. NCCN clinical practice guidelines in oncology: Non-Small Cell Lung Cancer[S]. Vesion 1, 2010. NCCN 2010.
[18]
WangJ,ChenJ,ChenX, et al. Blood vessel invasion as a strong independent prognostic indicator in non-small cell lung cancer: a systematic review and meta-analysis[J]. PLoS One,2011,6(12):e28844.
[19]
TsuchiyaT,HashizumeS,AkamineS, et al. Upstaging by vessel invasion improves the pathology staging system of non-small cell lung cancer[J]. Chest, 2007 ,132(1):170-177.
[20]
RuffiniE,AsioliS,FilossoPL, et al. Significance of the presence of microscopic vascular invasion after complete resection of Stage I-II pT1-T2N0 non-small cell lung cancer and its relation with T-Size categories: did the 2009 7th edition of the TNM staging system miss something [J]? J Thorac Oncol, 2011,6(2):319-326.
[21]
KudoY,SajiH,ShimadaY, et al. Proposal on incorporating blood vessel invasion into the T classification parts as a practical staging system for stage I non-small cell lung cancer[J]. Lung Cancer, 2013,81(2):187-193.
[22]
HamanakaR,YokoseT,SakumaY, et al. Prognostic impact of vascular invasion and standardization of its evaluation in stage I non-small cell lung cancer[J]. Diagn Pathol, 2015,10:17.
[23]
ShimadaY,SajiH,KatoY, et al. The frequency and prognostic impact of pathological microscopic vascular invasion according to tumor size in non-small cell lung cancer[J]. Chest, 2016,149(3):775-785.
[24]
NeriS,YoshidaJ,IshiiG, et al. Prognostic impact of microscopic vessel invasion and visceral pleural invasion in non-small cell lung cancer: a retrospective analysis of 2657 patients[J]. Ann Surg, 2014,260(2):383-388.
[25]
VieiraT,AntoineM,RuppertAM, et al. Blood vessel invasion is a major feature and a factor of poor prognosis in sarcomatoid carcinoma of the lung[J]. Lung Cancer,2014 ,85(2):276-281.
[1] 张思平, 刘伟, 马鹏程. 全膝关节置换术后下肢轻度内翻对线对疗效的影响[J]. 中华关节外科杂志(电子版), 2023, 17(06): 808-817.
[2] 李越洲, 张孔玺, 李小红, 商中华. 基于生物信息学分析胃癌中PUM的预后意义[J]. 中华普通外科学文献(电子版), 2023, 17(06): 426-432.
[3] 张俊, 罗再, 段茗玉, 裘正军, 黄陈. 胃癌预后预测模型的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 456-461.
[4] 杨倩, 李翠芳, 张婉秋. 原发性肝癌自发性破裂出血急诊TACE术后的近远期预后及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 33-36.
[5] 栗艳松, 冯会敏, 刘明超, 刘泽鹏, 姜秋霞. STIP1在三阴性乳腺癌组织中的表达及临床意义研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 52-56.
[6] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[7] 江振剑, 蒋明, 黄大莉. TK1、Ki67蛋白在分化型甲状腺癌组织中的表达及预后价值研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 623-626.
[8] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[9] 鲁鑫, 许佳怡, 刘洋, 杨琴, 鞠雯雯, 徐缨龙. 早期LC术与PTCD续贯LC术治疗急性胆囊炎对患者肝功能及预后的影响比较[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 648-650.
[10] 姜明, 罗锐, 龙成超. 闭孔疝的诊断与治疗:10年73例患者诊疗经验总结[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 706-710.
[11] 钟广俊, 刘春华, 朱万森, 徐晓雷, 王兆军. MRI联合不同扫描序列在胃癌术前分期诊断及化疗效果和预后的评估[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 378-382.
[12] 胡宝茹, 尚乃舰, 高迪. 中晚期肝细胞癌的DCE-MRI及DWI表现与免疫治疗预后的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 399-403.
[13] 李永胜, 孙家和, 郭书伟, 卢义康, 刘洪洲. 高龄结直肠癌患者根治术后短期并发症及其影响因素[J]. 中华临床医师杂志(电子版), 2023, 17(9): 962-967.
[14] 王军, 刘鲲鹏, 姚兰, 张华, 魏越, 索利斌, 陈骏, 苗成利, 罗成华. 腹膜后肿瘤切除术中大量输血患者的麻醉管理特点与分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 844-849.
[15] 索利斌, 刘鲲鹏, 姚兰, 张华, 魏越, 王军, 陈骏, 苗成利, 罗成华. 原发性腹膜后副神经节瘤切除术麻醉管理的特点和分析[J]. 中华临床医师杂志(电子版), 2023, 17(07): 771-776.
阅读次数
全文


摘要