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中华胸部外科电子杂志 ›› 2017, Vol. 04 ›› Issue (01) : 56 -62. doi: 10.3877/cma.j.issn.2095-8773.2017.01.11

所属专题: 文献

综述

表皮生长因子受体相关靶向治疗与肺癌的研究进展
王丹云1,(), 彭忠民2   
  1. 1. 250013 山东大学附属济南市中心医院普胸外科
    2. 250021 山东大学附属省立医院普胸外科
  • 收稿日期:2016-10-14 出版日期:2017-02-28
  • 通信作者: 王丹云

Research progress of EGFR related targeted therapy and pulmonary carcinoma

Danyun Wang1,(), Zhongmin Peng2   

  1. 1. Department of General Thoracic Surgery, Jinan Center Hospital affiliated to Shandong University, Jinan 250013, China
    2. Department of General Thoracic Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan250021, China
  • Received:2016-10-14 Published:2017-02-28
  • Corresponding author: Danyun Wang
  • About author:
    Corresponding author: Wang Danyun, Email:
引用本文:

王丹云, 彭忠民. 表皮生长因子受体相关靶向治疗与肺癌的研究进展[J/OL]. 中华胸部外科电子杂志, 2017, 04(01): 56-62.

Danyun Wang, Zhongmin Peng. Research progress of EGFR related targeted therapy and pulmonary carcinoma[J/OL]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2017, 04(01): 56-62.

近年来,非小细胞肺癌(NSCLC)的治疗进展主要以分子靶向治疗为主导地位。依据组织和分子学类型制定个体化治疗方案已成为靶向治疗时代的准则,表皮生长因子受体(EGFR)基因是目前肺癌众多驱动基因中研究最多、证据最充分、了解最透彻的一个分子靶点。表皮生长因子酪氨酸激酶抑制剂(EGFR-TKI)已广泛应用于EGFR突变的NSCLC。该文将EGFR相关靶向药物在NSCLC的治疗进展做一综述。

During the past several years, advances in the treatment of non-small cell lung cancer (NSCLC) have predominantly involved the development of therapies directed at molecular targets. Treatment based on histology and molecular characterization has become a guideline of care in the era of targeted therapy. Among numerous driver genes of NSCLC, epidermal growth factor receptor(EGFR) gene is one molecular target concerning with most researches, abundant evidences and thorough understandings. Epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI) has been widely used in the treatment of NSCLC haboring EGFR mutation. This review provides an overview of current EGFR gene related targeted therapies in NSCLC.

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