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中华胸部外科电子杂志 ›› 2026, Vol. 13 ›› Issue (02) : 140 -146. doi: 10.3877/cma.j.issn.2095-8773.2026.02.07

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中国肺移植长期生存率的挑战与提升策略
张培1,2, 孙长博1,2, 张坤鹏1,2, 凌新宇1,2, 戴晨阳1,2, 王龙1,2, 曹足3, 吴俊琪1,2, 陈昶1,2,()   
  1. 1200433 上海,同济大学附属上海市肺科医院胸外科
    2200433 上海,上海肺移植工程技术研究中心
    3200433 上海,同济大学附属上海市肺科医院呼吸与危重症医学科
  • 收稿日期:2026-01-30 修回日期:2026-03-04 接受日期:2026-05-08 出版日期:2026-05-28
  • 通信作者: 陈昶
  • 基金资助:
    "四大慢病"国家科技重大专项(2024ZD0529000); 国家自然科学基金(82500152)

Challenges and strategies for improving long-term survival rates in lung transplant recipients in China

Pei Zhang1,2, Changbo Sun1,2, Kunpeng Zhang1,2, Xinyu Ling1,2, Chenyang Dai1,2, Long Wang1,2, Zu Cao3, junqi Wu1,2, Chang Chen1,2,()   

  1. 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
    2Shanghai Engineering Research Center of Lung Transplantation, Shanghai 200433, China
    3Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
  • Received:2026-01-30 Revised:2026-03-04 Accepted:2026-05-08 Published:2026-05-28
  • Corresponding author: Chang Chen
引用本文:

张培, 孙长博, 张坤鹏, 凌新宇, 戴晨阳, 王龙, 曹足, 吴俊琪, 陈昶. 中国肺移植长期生存率的挑战与提升策略[J/OL]. 中华胸部外科电子杂志, 2026, 13(02): 140-146.

Pei Zhang, Changbo Sun, Kunpeng Zhang, Xinyu Ling, Chenyang Dai, Long Wang, Zu Cao, junqi Wu, Chang Chen. Challenges and strategies for improving long-term survival rates in lung transplant recipients in China[J/OL]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2026, 13(02): 140-146.

中国肺移植在新时期经历了二十余年的快速发展后,手术量已跃居国际前列,围手术期生存率接近国际先进水平。然而,我国肺移植长期生存率(尤其是5年及以上的存活率)与国际先进的移植中心相比仍有较大差距。本文将分析中国肺移植长期生存率的三大挑战:感染与免疫抑制的平衡、慢性移植物功能障碍(CLAD)的管理以及终身随访体系的建立。并在此基础上提出了以"围手术期精细化管理"及"终身管理"为核心的提升策略。肺移植长期生存率的提升不仅需要不断攻关手术技术环节,还需要建立以长期生存率为目标、高级别循证证据为导向、多学科合作为基础的终身管理理念。

After more than two decades of rapid development in the new era, the volume of lung transplant surgeries in China now ranks among the top internationally, with the perioperative survival rate now approaching internationally advanced levels. However, the long-term survival rate of lung transplantation in China—particularly the 5-year and beyond survival rate—still lags behind that of leading international transplant centers. This article will analyze three major challenges affecting long-term survival in China: balancing infection and immunosuppression, managing chronic lung allograft dysfunction (CLAD), and establishing a lifelong follow-up system. Based on this analysis, specific strategies centered on "meticulous perioperative management" and "lifelong management" are proposed. Enhancing the long-term survival rate of lung transplantation requires not only continuous breakthroughs in surgical techniques but also the establishment of a lifelong management philosophy aimed at long-term survival, guided by high-level evidence, and founded on multidisciplinary collaboration.

表1 中国对比国外肺移植生存率数据
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