Research progress of clinical translating tissue-engineered tracheal replacement

doi:10.3877/cma.j.issn.2095-8773.2015.02.003

Abstract

Abstract:

Objective

There are a variety of trachea diseases with different clinical settings, which may extend from a surgical approach to total organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissues in the body, which seems to be a promising approach for tracheareplacement.It has now become evident that the key factors for successful clinical tissue engineering include a scaffold or matrix of natural or synthetic origin, autologous or allogeneic cells, a bioreactor to mimic the physiologic environment (in vitro or in vivo), as well as site-specific tissue protection by means of biomolecule/pharmacologic intervention. This review elaborates on the essential components of the tissue-engineering approach, and discusses the progress of the revolutionary trachea clinical transplantation.

Key words: Tissue engineering, Trachea, Clinical transplantation

Fei Sun, Hongcan Shi. Research progress of clinical translating tissue-engineered tracheal replacement[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2015, 02(02): 88-93.

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