Clinical characteristics and prognostic analysis of lung adenocarcinoma

doi:10.3877/cma.j.issn.2095-8773.2015.02.008

Abstract

Abstract:

Objective

To investigate the clinicopathological characteristics and prognosis of lung adenocarcinoma undergoing resection, and explore the its prognostic factors.

Methods

The clinical data of 109 cases of lung adenocarcinoma undergoing resection were retrospectively reviewed. Univariate analysis of clinicopathological characteristics was performed, and the statistically significant factors were included in multivariate analysis.

Results

For the 109 cases of lung adenocarcinoma, the overall 5-year survival was 44.0%(48/109). Univariate analysis revealed that tumor size(χ²=8.995, P=0.003), lymph node status(χ²=12.727, P=0.0000), TNM stage(χ²=39.544, P=0.000), surgical margin(χ²=35.551, P=0.000)and expression of PCNA(χ²=5.441, P=0.020) influenced survival time. Multivariate analysis indicated that tumor size, TNM stage, and surgical margin were independent prognostic factors of lung adenocarcinoma (P<0.05), and postoperative chemotherapy was prognostic factors of stageⅡ and Ⅲ lung adenocarcinoma(χ²=11.299, P=0.001).

Conclusion

Tumor size, higher TNM stage and positive surgical margin may be important factors of unfavorable prognosis of lung adenocarcinoma, and patients with stage Ⅱ and Ⅲ lung adenocarcinoma may gain benefits from postoperative adjuvant chemotherapy.

Key words: Lung neoplasm, Lung adenocarcinoma, Univariate analysis, Multivariate analysis, prognosis

Weigui Yang, Hualing Ma. Clinical characteristics and prognostic analysis of lung adenocarcinoma[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2015, 02(02): 114-118.

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https://zhxbwkdzzz.cma-cmc.com.cn/EN/Y2015/V02/I02/114

Figures/Tables 4

References 14

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因素		例数	中位生存时间(月)	χ²值	P值
性别		?	?	?	?
?	男性	067	46	0.194	0.661
?	女性	042	52	0.194	0.661
年龄		?	?	?	?
?	≤60岁	048	49	0.058	0.810
?	>60岁	061	47	0.058	0.810
肿瘤最大径		?	?	?	?
?	≤3 cm	041	61	8.995	0.003
?	>3 cm	068	45	8.995	0.003
淋巴结转移		?	?	?	?
?	N₀	060	58	12.727	0.000
?	N_1-2	049	39	12.727	0.000
TNM分期		?	?	?	?
?	ⅠA＋ⅠB期	043	69	39.544	0.000
?	ⅡA＋ⅡB期	039	45
?	ⅢA＋ⅢB期	027	34
肿瘤分化程度		?	?	?	?
?	分化好	032	52	2.506	0.113
?	其他	077	46	2.506	0.113
支气管残端癌残留		?	?	?	?
?	有	006	18	35.551	0.000
?	无	103	49	35.551	0.000
PCNA表达		?	?	?	?
?	阳性	066	42	5.441	0.020
?	阴性	043	64	5.441	0.020
手术方式		?	?	?	?
?	肺叶切除术	086	47	0.534	0.465
?	全肺切除术	006	46
?	袖式切除术	007	42
?	肺段切除术	010	59

因素		例数	中位生存时间(月)	χ²值	P值
性别		?	?	?	?
?	男性	067	46	0.194	0.661
?	女性	042	52	0.194	0.661
年龄		?	?	?	?
?	≤60岁	048	49	0.058	0.810
?	>60岁	061	47	0.058	0.810
肿瘤最大径		?	?	?	?
?	≤3 cm	041	61	8.995	0.003
?	>3 cm	068	45	8.995	0.003
淋巴结转移		?	?	?	?
?	N₀	060	58	12.727	0.000
?	N_1-2	049	39	12.727	0.000
TNM分期		?	?	?	?
?	ⅠA＋ⅠB期	043	69	39.544	0.000
?	ⅡA＋ⅡB期	039	45
?	ⅢA＋ⅢB期	027	34
肿瘤分化程度		?	?	?	?
?	分化好	032	52	2.506	0.113
?	其他	077	46	2.506	0.113
支气管残端癌残留		?	?	?	?
?	有	006	18	35.551	0.000
?	无	103	49	35.551	0.000
PCNA表达		?	?	?	?
?	阳性	066	42	5.441	0.020
?	阴性	043	64	5.441	0.020
手术方式		?	?	?	?
?	肺叶切除术	086	47	0.534	0.465
?	全肺切除术	006	46
?	袖式切除术	007	42
?	肺段切除术	010	59

变量	B	SE	Wald	自由度	检验值	Exp(B)
肿瘤大小	0.471	0.227	4.289	1	0.038	1.601
淋巴结有无转移	0.075	0.290	0.067	1	0.796	1.078
TMN分期	0.759	0.211	12.889	1	0.000	2.137
支气管残端有无癌残留	1.724	0.501	11.824	1	0.001	2.008
PCNA	0.097	0.207	0.218	1	0.641	1.102

变量	B	SE	Wald	自由度	检验值	Exp(B)
肿瘤大小	0.471	0.227	4.289	1	0.038	1.601
淋巴结有无转移	0.075	0.290	0.067	1	0.796	1.078
TMN分期	0.759	0.211	12.889	1	0.000	2.137
支气管残端有无癌残留	1.724	0.501	11.824	1	0.001	2.008
PCNA	0.097	0.207	0.218	1	0.641	1.102

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