Abstract:
Objective To explore the risk factors for recurrent laryngeal nerve paralysis(RLNP) after esophagectomy, analyze the influence of RLNP on the completion rate of adjuvant therapy and long-term survival.
Methods The clinical and pathological data of 762 consecutive cases of esophageal squamous cell carcinoma in the department of thoracic surgery, Shanghai chest hospital from January 2013 to December 2015 were analyzed retrospectively.
Results The incidence of RLNP in this study was 13.6%. Multivariate analysis showed that McKeown procedure and lymph node metastasis along the recurrent laryngeal nerve were independent risk factors for RLNP(P<0.05). The results of survival analysis showed that 3 years-OS of RLNP group was lower than that of no RLNP group (47.9% vs 50.9%), 3 years-DFS of RLNP group was lower than that of no RLNP group (41.6% vs 42.6%), but the difference were not statistically significant (P>0.05). The 3 years-OS of RLNP-delayed adjuvant therapy group was lower than that of no RLNP group (48.4% vs 57.1%), and 3 years-DFS of RLNP-delayed adjuvant therapy group was lower than that of no RLNP group (38.7% vs 47.3%), but the difference was not statistically significant (P>0.05).
Conclusions Lymph node metastasis along the recurrent laryngeal nerve were independent risk factors for RLNP. Adjuvant chemotherapy was delayed by RLNP which may deteriorate long-term prognosis of histological node positive patients.
Key words:
Esophageal cancer,
Recurrent laryngeal nerve paralysis,
Adjuvant therapy
Xufeng Guo, Xiaobing Zhang, bing Li, Haiyong Gu, Yu Yang, Yifeng Sun, Bo Ye, Rong Hua, Teng Mao, Zhigang Li. Influence of recurrent laryngeal nerve paralysis after esophagectomy on the completion rate of adjuvant therapy and long-term survival[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2018, 05(02): 75-79.