Progress of application of indocyanine green fluorescent tracer in gastro-esophageal surgery

doi:10.3877/cma.j.issn.2095-8773.2018.02.11

Abstract

Abstract:

Technical developments in near-infrared fluorescence (NIRF) imaging have made it play a critical role in various fields of surgery. Indocyanine green (ICG) is a new type of fluorochrome that can stain tissues under the near-infrared fluorescence during surgery. Non-invasive imaging of the lymphatic vasculature for intraoperative diagnosis and assessment of function has been uniquely accomplished with NIR using indocyanine green (ICG). In this review, we mainly discuss the application of ICG fluorescent tracer in gastro-esophageal surgery. There are two main fields where ICG fluorescent tracer can be applied: intraoperative sentinel lymph node mapping and biopsy; video-angiography assessing vascular circulation in reconstructive surgery. Because ICG is still in its nascent stages, more studies need to be carried out to fully evaluate its potential.

Key words: Indocyanine green, Near-infrared fluorescence, Gastro-esophageal surgery, Sentinel lymph node, Angiography

Haoyao Jiang, Zhigang Li. Progress of application of indocyanine green fluorescent tracer in gastro-esophageal surgery[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2018, 05(02): 124-128.

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作者(出版时间)	样本量	肿瘤类型	手术方式	ICG剂量	注射部位	显影SLN病例数[(n/N(%)]	平均SLN个数	假阴性[(n/N(%)]
Hiratsuka等^[7](2001)	74	胃癌	开放	5 ml	环周浆膜下	73/74 (98.6)	2.6	1/10(10.0)
Tajima等^[8](2009)	56	胃癌	未知	2 ml	术前黏膜下、术中浆膜下	54/56(96.4)	7.2	6/17 (35.3)
Miyashiro等^[9](2011)	10	胃癌	腹腔镜	2～4 ml	环周黏膜下	10/10(100.0)	3.1	未知
Hironori等^[10](2017)	6	胃癌	腹腔镜	0.5 ml	环周黏膜下	6/6(100.0)	7	未知
Tummers^[11](2016)	22	胃癌	开放	1.6 ml	环周浆膜下	21/22 (95.5)	3.1	未知
Kusano等^[12](2008)	48	胃癌22例；结肠癌26例	腹腔镜、开放	2 ml	环周浆膜下	20/22(90.9)；23/26(88.5)	3.6；2.6	6/10(60.0)；4/6(66.7)
Noura等^[13](2009)	25	结肠癌	腹腔镜	1 ml	未知	23/25 (92.0)	2.1	未知
Chand等^[14](2017)	10	结肠癌	腹腔镜	1 ml	环周浆膜下	8/10(80.0)	未知	未知
Hachey等^[15](2016)	9	食管癌	胸腔镜	1 ml	环周黏膜下	6/9(66.7)	3	未知

作者(出版时间)	样本量	肿瘤类型	手术方式	ICG剂量	注射部位	显影SLN病例数[(n/N(%)]	平均SLN个数	假阴性[(n/N(%)]
Hiratsuka等^[7](2001)	74	胃癌	开放	5 ml	环周浆膜下	73/74 (98.6)	2.6	1/10(10.0)
Tajima等^[8](2009)	56	胃癌	未知	2 ml	术前黏膜下、术中浆膜下	54/56(96.4)	7.2	6/17 (35.3)
Miyashiro等^[9](2011)	10	胃癌	腹腔镜	2～4 ml	环周黏膜下	10/10(100.0)	3.1	未知
Hironori等^[10](2017)	6	胃癌	腹腔镜	0.5 ml	环周黏膜下	6/6(100.0)	7	未知
Tummers^[11](2016)	22	胃癌	开放	1.6 ml	环周浆膜下	21/22 (95.5)	3.1	未知
Kusano等^[12](2008)	48	胃癌22例；结肠癌26例	腹腔镜、开放	2 ml	环周浆膜下	20/22(90.9)；23/26(88.5)	3.6；2.6	6/10(60.0)；4/6(66.7)
Noura等^[13](2009)	25	结肠癌	腹腔镜	1 ml	未知	23/25 (92.0)	2.1	未知
Chand等^[14](2017)	10	结肠癌	腹腔镜	1 ml	环周浆膜下	8/10(80.0)	未知	未知
Hachey等^[15](2016)	9	食管癌	胸腔镜	1 ml	环周黏膜下	6/9(66.7)	3	未知

作者(出版时间)	样本量	类型	ICG剂量(mg)	给药途径	成功显影(%)	改变术式	瘘[n(%)]	改变术式瘘[n(%)]
Frederic等(2014)	30	结肠	25	静脉	96.7	3	0	0(0)
Mehraneh等^[20](2015)	139	结肠	3.75～ 7.5	静脉	99	11	2(1.4)	0(0)
Rino等^[21](2014)	33	食管	2.5	静脉	100	0	5(15.2)	0(0)
Koyanagi等^[22](2016)	40	食管	1.25或2.5	中心静脉	100	0	7(17.5)	0(0)
Kubota等^[23](2013)	5	食管	5	静脉	100	0	0(0)	0(0)
Ohi等^[24](2017)	59	食管	2.5	静脉	100	未做荧光61例	1(1.7)	9 (14.7)

作者(出版时间)	样本量	类型	ICG剂量(mg)	给药途径	成功显影(%)	改变术式	瘘[n(%)]	改变术式瘘[n(%)]
Frederic等(2014)	30	结肠	25	静脉	96.7	3	0	0(0)
Mehraneh等^[20](2015)	139	结肠	3.75～ 7.5	静脉	99	11	2(1.4)	0(0)
Rino等^[21](2014)	33	食管	2.5	静脉	100	0	5(15.2)	0(0)
Koyanagi等^[22](2016)	40	食管	1.25或2.5	中心静脉	100	0	7(17.5)	0(0)
Kubota等^[23](2013)	5	食管	5	静脉	100	0	0(0)	0(0)
Ohi等^[24](2017)	59	食管	2.5	静脉	100	未做荧光61例	1(1.7)	9 (14.7)

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