Clinical efficacy and traumatic reaction of single-port video-assisted thoracoscopic surgery for non-small cell lung cancer

doi:10.3877/cma.j.issn.2095-8773.2019.03.04

Abstract

Abstract:

Objective

To investigate the clinical efficacy and traumatic reaction of single-port video-assisted thoracoscopic surgery (VATS) in the treatment of non-small cell lung cancer (NSCLC) .

Methods

Seventy patients with NSCLC admitted to Department of Thoracic Surgery , Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2015 to October 2018 underwent radical resection of lung cancer . They were divided into single-port VATS group and multihole VATS group according to different surgical methods ,with 35 cases in each group . The following clinical data including blood volume , operation time , extubation time , satisfaction score , incidence of complications ,WBC count ,C-reactive protein (CRP) level and cellular immune function (CD 4^＋/CD8^＋T lymphocyte subsets) were compared between the two groups .

Results

The patients with single-port VATS had less bleeding ,shorter operation time and extubation time ,and higher satisfaction score than those with multi-hole VATS ( P＜0 .05) .On the 1st and 7th day after operation , the WBC count and CRP value of the patients in the single-port VATS group were much lower than those in the multi-hole VATS group( P＜0 .05) ;and the ratio of CD4^＋/CD8^＋T lymphocyte subsets of the patients in the singleport VATS group were much higher than those in the multi-hole VATS group( P＜0 .05) .The VAS score of pain on the first day and the seventh day after operation was significantly lower in the single-port VATS group than in the porous VATS group ( P＜0 .05) .The total incidence of complications in singleport VATS group was 8 .57% , and that in porous VATS group was 31 .43% . The difference was statistically significant (χ² ＝14 .9331 , P＜0 .01) .

Conclusions

Single-port VATS surgery for NSCLC is a treatment with clinical significance and high safety ,as the body would has less traumatic stress reaction ,less complications ,less pain ,and faster recovery ,which is worthy of clinical application .

Key words: Lung cancer, Thoracoscopy, Pain, Traumatic reaction

Zhanliang Ren, Wei feng Zhang, Yong Zhang, Xiaopeng Ren, Taiping He, Jinhua Li, Shan Gao. Clinical efficacy and traumatic reaction of single-port video-assisted thoracoscopic surgery for non-small cell lung cancer[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2019, 06(03): 156-160.

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References 13

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组别	出血量（ml）	手术时间（min）	拔管时间（d）	满意度（分）
单孔VATS组（ｎ＝35）	241.8±28.9	158.5±25.8	3.8±1.5	4.6±1.1
多孔VATS组（ｎ＝35）	308.9±37.7	183.3±19.1	5.6±1.9	3.5±1.9
ｔ值	8.369	4.572	4.460	－3.084
Ｐ值	＜0.001	＜0.001	＜0.001	0.003

组别	出血量（ml）	手术时间（min）	拔管时间（d）	满意度（分）
单孔VATS组（ｎ＝35）	241.8±28.9	158.5±25.8	3.8±1.5	4.6±1.1
多孔VATS组（ｎ＝35）	308.9±37.7	183.3±19.1	5.6±1.9	3.5±1.9
ｔ值	8.369	4.572	4.460	－3.084
Ｐ值	＜0.001	＜0.001	＜0.001	0.003

组别	术后第1天	术后第7天
单孔VATS组（ｎ＝35）	2.6±0.2	3.0±0.7
多孔VATS组（ｎ＝35）	5.3±0.7	3.5±0.9
ｔ值	22.027	3.051
Ｐ值	＜0.001	0.003

组别	术后第1天	术后第7天
单孔VATS组（ｎ＝35）	2.6±0.2	3.0±0.7
多孔VATS组（ｎ＝35）	5.3±0.7	3.5±0.9
ｔ值	22.027	3.051
Ｐ值	＜0.001	0.003

组别	WBC（×10⁹／L）		CRP（mg／L）		CD4^＋／CD8^＋
组别	术后第1天	术后第7天	术后第1天	术后第7天	术后第1天	术后第7天
单孔VATS组（ｎ＝35）	11.1±2.5	9.4±1.7	54.9±14.7	25.4±15.7	1.6±0.5	1.7±0.6
多孔VATS组（ｎ＝35）	13.3±3.0	11.5±2.2	70.5±16.4	36.9±14.2	1.2±0.4	1.3±0.4
ｔ值	3.288	4.586	4.191	3.207	－4.312	－3.234
Ｐ值	0.002	＜0.001	＜0.001	0.002	＜0.001	0.002

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