To understand the changes of nutritional status of patients with esophageal cancer who underwent neoadjuvant therapy before and after surgery, and analyze the relevant factors to provide evidence for improving postoperative nutritional status of patients.

142 patients with esophageal cancer accepted by the Fourth Affiliated Hospital Hebei Medical University from May 1st 2017 to May 31th 2019 were randomly selected for this study. The clinical records of these patients were collected by electronic medical record system. The physiological-biochemical index of those patients before and after the neoadjuvant esophageal cancer surgery were compared, including the levels of prealbumin(PA), albumin (Alb), total protein(TP), globulin(Glob), hemoglobin(Hgb), total lymphocyte count(TLC), glutamic-pyruvic transaminase(GPT), glutamic-oxaloacetic transaminase(GOT) , creatinine(Cr), and urea nitrogen(UN).

Compared with before the surgery, the patients’ nutritional indicators after surgery including albumin (Alb), prealbumin(PA), total protein(TP), hemoglobin(Hgb), globulin(Glob), total lymphocyte count(TLC) levels were significantly reduced(P<0.001). The patients’ liver function index including glutamic-pyruvic transaminase(GPT) and glutamic-oxaloacetic transaminase(GOT) were significantly increased(P< 0.001). However, the level of creatinine(Cr) and the urea nitrogen(UN) is slightly increased, but there was no statistically significant difference (P> 0.05).

Surgical treatment significantly reduces the nutritional status of neoadjuvant esophageal cancer patients, and has a great impact on the liver function of the patients. Therefore, clinicians should pay attention to it and timely implement nutritional intervention measures to improve the postoperative nutritional status of the patients.