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Chinese Journal of Thoracic Surgery(Electronic Edition) ›› 2019, Vol. 06 ›› Issue (04): 248-252. doi: 10.3877/cma.j.issn.2095-8773.2019.04.09

Special Issue:

• Review • Previous Articles     Next Articles

Expression and mechanism of G protein-coupled receptors in human lower esophageal sphincter

Ke Zhang1,(), Cong Zhang2, Jing Gao2, Haichen Wang3, Caina Han4, Wei Zang5, Junfeng Liu6   

  1. 1. Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China;Basic Research Key Laboratory of General Surgery for Digital Medicine, Baoding 071000, China
    2. Department of Pre-hospital Emergency, The First Center Hospital of Baoding City, Baoding 071000, China
    3. The Third Department of Medical Imaging, The First Center Hospital of Baoding City, Baoding 071000, China
    4. Department of Critical Medicine, The First Center Hospital of Baoding City, Baoding 071000, China
    5. The Third Department of Laboratory Medicine, The First Center Hospital of Baoding City, Baoding 071000, China
    6. Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China
  • Received:2019-04-21 Online:2019-11-28 Published:2019-11-28
  • Contact: Ke Zhang
  • About author:
    Corresponding author: Zhang Ke, Email:

Abstract:

The lower esophageal sphincter (LES) includes three ways of regulation: nerve-regulation, self-regulation and body fluid regulation. Among the three ways, humoral regulation involves a variety of hormones, but all of them play a role in binding with G protein-coupled receptors (GPCRs). Because of the different regulatory functions of ligands and receptors, hormone substances also have different regulatory functions. Through the study of its mechanism, we found that through further research and development, it is expected to treat esophageal motility diseases through drug regulation.

Key words: Lower esophageal sphincter, Nerve-regulation, Self-regulation, Body fluid regulation, G protein-coupled receptors, Esophageal motility diseases

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