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Chinese Journal of Thoracic Surgery(Electronic Edition) ›› 2025, Vol. 12 ›› Issue (02): 105-111. doi: 10.3877/cma.j.issn.2095-8773.2025.02.05

• Review • Previous Articles     Next Articles

The research progress and prospects of targeting cancer-associated fibroblasts in lung cancer therapy

Qianhe Ren1, Susu Yang2, Yue Yu3,()   

  1. 1. Department of Thoracic Surgery,Northern Jiangsu People's Hospital,Yangzhou 225002,China
    2. Department of Breast Surgery,Jiangsu Provincial People's Hospital,Nanjing 210029,China
    3. Department of Thoracic Surgery,Jiangsu Provincial People's Hospital,Nanjing 210029,China
  • Received:2025-02-28 Revised:2025-04-10 Accepted:2025-05-06 Online:2025-05-28 Published:2025-07-01
  • Contact: Yue Yu

Abstract:

Current therapeutic strategies for lung cancer remain suboptimal, underscoring the urgent need for novel treatment approaches and targets of clinical relevance.In recent years,a growing body of evidence has highlighted the pivotal role of tumor microenvironment (TME) abnormalities in the initiation and progression of lung cancer.Among the various stromal components,cancer-associated fibroblasts (CAFs) have emerged as key regulators of the malignant phenotype,significantly influencing tumor cell proliferation,invasion,and metastasis.As integral constituents of the TME,CAFs are essential for maintaining normal cellular physiology.However,when aberrantly activated within the tumor milieu,CAFs are closely associated with the aggressive biological behavior of cancer cells.Elucidating the mechanistic roles of CAFs in lung cancer and evaluating their potential as therapeutic targets hold considerable promise for advancing treatment outcomes.

Key words: Lung cancer, Cancer-associated fibroblasts, Immunotherapy, Prognosis

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