General situation of tracheal xenotransplantation

doi:10.3877/cma.j.issn.2095-8773.2016.01.051

Abstract

Abstract:

Tracheal xenotransplantation is still in the stage of animal experiments and has not been used in clinical practice, largely because the problem of immunological rejection following xenotransplantation has not been settled and the ethical dispute is also a controversial issue. The preservation and revascularization of xenografts remain to be solved. The key to success of tracheal xenotransplantation depends on eliminating the immunological rejection. The general situation of tracheal xenotransplantation on its research progress and challenges is introduced in this paper.

Key words: Trachea, Xenotransplantation, Immunological rejection

Tao Lu, Yu Liu. General situation of tracheal xenotransplantation[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2016, 03(01): 51-55.

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References 30

[1]	PHS Guideline on Infectious Disease Issues in Xenotransplantation (USA)[R/OL]．[2005-01-15]． URL
[2]	NakanoshiR. Revascularization of trachea in lung and tracheal transplantation [J]. Clin Translant，2007，21(5)：668-674.
[3]	LiuY,NakamuraT,ShimizuY, et al. Tracheal allotransplantation in beagle dogs without immunosuppressants[J]. Ann Thorac Surg，2001，72(4)：1190-1194.
[4]	史宏灿，徐志飞. 气管移植再血管化的研究进展[J]．国外医学外科学分册，2002，29(2)：99-101.
[5]	林村河，刘琨. 气管移植的研究进展[J]. 中国胸心血管外科杂志，2000，7(1)：51-54.
[6]	YokomiseH,InuiK,WadaH, et al. Reliable cryopreservation of trachea for one month in a new trehalose solution[J]. J Thorac Cardiovasc Surg，1995，110(2)：382-385.
[7]	VadoriM,CozziE. The immunological barriers to xenotransplantation [J]. Tissue Antigens，2015，86(4)：239-253.
[8]	ScholzelE,PetropoulosP,SpycherM, et al. Revitalization of bovine xenograft used for repair of experimental tracheal defects[J]. Thoraxchir Vask Chir, 1978，26(3)：172-176.
[9]	LametschwandtnerA,StaindlO,TholoS. Experimental heterograft tracheal transplants in animals.Ⅲ.Light microscopic，scanning and electron microscopic findings[J]. HNO，1980，28(2)：37-42.
[10]	FantaJ,PohunkováH,StolM, et al. Tracheal replacement with a swine prosthesis [J]. Rozhl Chir，1995，74(5)：206-210.
[11]	KawaharaK,HiratsukaM,MikamiK, et al. Obliterative airway disease and graft stenting in pig-to-dog tracheal xenotransplantation[J]. Jpn J Thorac Cardiovasc Surg，2001，49(1)：53-57.
[12]	ShiHC,DengWJ,PeiC, et al. Biomechanical properties of adult-excised porcine trachea for tracheal xenotransplantation[J]. Xenotransplantation, 2009，16(3)：181-186.
[13]	窦科峰．异种移植学[M]//窦科峰，李俊杰. 异种移植学基本概念. 北京：人民军医出版社，2014：17-35.
[14]	ReichenspurnerH,GirgisRE,RobbinsRC, et al. Obliterative-bronchiolitis after lung and heart-lung transplantation[J]. Ann Thorac Surg，1995，60(6): 1845-1853.
[15]	WallgrenAC,Karlsson-ParraA,KorsgrenO. The main infiltrating cell in xenograft rejection is a CD4^＋ macrophage and not a T lymphocyte[J]. Transplantation，1995，60(6)：594-601.
[16]	FoxA,MountfordJ,BraakhuisA, et al. Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection[J]. J Immunol，2001，166(3)：2133-2140.
[17]	KuoE,MaruyamaT,FernandezF, et al. Molecular mechanisms of chronic rejection following transplantation[J]. Immunol Res，2005，32(1)：179-185.
[18]	YamadaK,ScaleaJ. Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers[J]. Methods Mol Biol，2012, 885：191-212.
[19]	赵勇，孙祖玥. 异种胸腺移植：受者细胞免疫力重建[J]. 国外医学：免疫学分册，2005，28(5)：257-259.
[20]	ReichenspurnerH,SoniV,NitschkeM. Obliterative airway disease after heterotopic topic tracheal xenotransplantation: pathogenesis and prevention using new immunosuppressive agents[J]. Transplantation，1997，64(3)：373-383.
[21]	HashimotoM,NakanishiR. Feasibility of cryopreserved tracheal xenotranspsants with the use of short-course immuno-suppression[J]. J Thorac Cardiovasc Surg, 2001，121(2)：241-248.
[22]	王林毛，吴凯，高文，等. 异位气管移植模型中上皮细胞的增殖与凋亡[J]. 中国组织工程研究与临床康复，2011，15(18)：3288-3292.
[23]	MunHS,KangHJ,LimKH, et al. Graft rejection in the xenogeneic transplantation of mice：diagnosis with in vivo MR imaging using the homing trait of macrophages[J]. Xenotransplantation，2008，15(4)：218-224.
[24]	MukaidaT,ShimizuN,AoeM, et al. Tracheal allotransplantation after varying terms of creyopreservation[J]. Transplantation Proceeding，1998，30(7)：3397-3400.
[25]	张启旭，周刚，王春梅，等. 非协调性异种气管移植的实验研究[J]. 中华整形外科杂志，2006，22(4)：309-313.
[26]	KushibeK,TojoT,SakaguchiH, et al. Effects of warm ischemia and cryopreservation on cartilage viability of tracheal allografts[J]. Ann Thorac Surg，2000，70(6)：1876-1879.
[27]	LiuY,NakamuraT,YamamotoY, et al. A new tracheal bioartificial organ: evolution of a tracheal allograft with minimal antigencity after treatment by detergent[J]. ASAIO J，2000，46(5)：536-539.
[28]	FianeAE,MollnesTE. Transplantation from animal to man[J]. Tidsskr Nor Laegeforen，1999，119(28)：4213-4218.
[29]	何秋明，李幼平，李胜富. 异种移植社会伦理问题[J]. 中国修复外科学杂志，1998, 12(6)：363-368.
[30]	BoksaM,ZeylandJ,SlomskiR, et al. Immune modulation in xenotransplantation [J]. Arch Immunol Ther Exp(Warsz)，2015，63(3)：181-192.

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