Application of 3D printed tracheal stents in the repair of long tracheal defects

doi:10.3877/cma.j.issn.2095-8773.2020.03.10

Abstract

Abstract:

The repair and reconstruction of long tracheal defects is a challenging problem in the clinic. Currently, the tracheal substitutes used for repair and reconstruction include allogeneic trachea, autologous tissue, artificial trachea and tissue engineered trachea. However, different tracheal substitutes have different shortcomings limiting its application in the clinic. 3D printing technology is a technology that has developed rapidly in recent years. Due to its personalized, precise, and fast characteristics, it has gradually been widely used in the medical field. More and more researchers have combined 3D printing technology with tissue engineering technology to study the repair and reconstruction of long tracheal defects, and have achieved some results.

Key words: 3D printing, Tissue engineering, Tracheal reconstruction

Kaifu Zheng, Yujian Liu, Xiyang Tang, Tao Jiang, Xiaofei Li, Jinbo Zhao. Application of 3D printed tracheal stents in the repair of long tracheal defects[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2020, 07(03): 191-196.

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References 26

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三点弯曲实验	支架材料	圆筒状	波纹状	原生气管
位移/载荷^[8]	PCL	1.4 mm/12.6 N	1.4 mm/1.8 N	—
抗压强度^[9]	PCL	—	1.088±0.161 MPa	0.214±0.125 MPa
受力分布^[8]	PCL	集中于受压点	均匀分布	—
旋转角度^[7]	PCL	110°±5°	130°±9°	—
旋转角度^[7]	PU	148°±10°	172°±8°	—

三点弯曲实验	支架材料	圆筒状	波纹状	原生气管
位移/载荷^[8]	PCL	1.4 mm/12.6 N	1.4 mm/1.8 N	—
抗压强度^[9]	PCL	—	1.088±0.161 MPa	0.214±0.125 MPa
受力分布^[8]	PCL	集中于受压点	均匀分布	—
旋转角度^[7]	PCL	110°±5°	130°±9°	—
旋转角度^[7]	PU	148°±10°	172°±8°	—

作者		年份	实验对象	气管构成	长度/mm	再生上皮	再生血管	再生软骨	随访时间
再上皮化		?	?	?	?	?	?	?	?
?	Bhora等^[12]	2017	猪	PCL+ECM	15	吻合口可见	广泛新生血管伴炎症细胞	—	2周
?	Park等^[13]	2018	新西兰兔	PCL+ECM+下鼻甲间充质干细胞	10	整个管腔可见	管腔中部可见	—	2个月
?	刘春全等^[14]	2018	新西兰兔	PLGA+软骨细胞	20	少量纤毛上皮	—	—	6个月
?	Chan等^[15]	2019	新西兰兔	PCL	20	吻合口可见	广泛新生血管伴炎症细胞	—	7周
再血管化		?	?	?	?	?	?	?	?
?	Gao等^[1]	2017	新西兰兔	PCL+软骨细胞+裸鼠皮下包埋	16.5	无上皮组织再生	—	部分区域可见	6周
?	Park等^[9]	2018	新西兰兔	PCL+大网膜包埋2周	15	整个管腔可见	大量新生血管	黏膜下可见少量软骨	8周
?	Gao等^[16]	2019	新西兰兔	PLLA+耳廓软骨细胞+颈旁肌肉包埋2周	15	整个管腔可见	大量新生血管	软骨细胞生存良好	2个月
软骨再生		?	?	?	?	?	?	?	?
?	Park等^[8]	2015	鼠（皮下）	PCL+TGF-β1+软骨细胞	15.5	—	—	软骨细胞生存良好	8周
?	葛阳等^[17]	2015	鼠（皮下）	聚酰胺+软骨细胞	20	—	—	软骨细胞生存良好	8周
?	张恒一等^[18]	2017	新西兰兔	PLCL+GT/PCL膜+软骨细胞	20	—	—	软骨细胞生存良好	8周
?	Xia等^[19]	2019	山羊	PCL+耳廓软骨细胞	30	部分区域可见	—	吻合口可见	8周

作者		年份	实验对象	气管构成	长度/mm	再生上皮	再生血管	再生软骨	随访时间
再上皮化		?	?	?	?	?	?	?	?
?	Bhora等^[12]	2017	猪	PCL+ECM	15	吻合口可见	广泛新生血管伴炎症细胞	—	2周
?	Park等^[13]	2018	新西兰兔	PCL+ECM+下鼻甲间充质干细胞	10	整个管腔可见	管腔中部可见	—	2个月
?	刘春全等^[14]	2018	新西兰兔	PLGA+软骨细胞	20	少量纤毛上皮	—	—	6个月
?	Chan等^[15]	2019	新西兰兔	PCL	20	吻合口可见	广泛新生血管伴炎症细胞	—	7周
再血管化		?	?	?	?	?	?	?	?
?	Gao等^[1]	2017	新西兰兔	PCL+软骨细胞+裸鼠皮下包埋	16.5	无上皮组织再生	—	部分区域可见	6周
?	Park等^[9]	2018	新西兰兔	PCL+大网膜包埋2周	15	整个管腔可见	大量新生血管	黏膜下可见少量软骨	8周
?	Gao等^[16]	2019	新西兰兔	PLLA+耳廓软骨细胞+颈旁肌肉包埋2周	15	整个管腔可见	大量新生血管	软骨细胞生存良好	2个月
软骨再生		?	?	?	?	?	?	?	?
?	Park等^[8]	2015	鼠（皮下）	PCL+TGF-β1+软骨细胞	15.5	—	—	软骨细胞生存良好	8周
?	葛阳等^[17]	2015	鼠（皮下）	聚酰胺+软骨细胞	20	—	—	软骨细胞生存良好	8周
?	张恒一等^[18]	2017	新西兰兔	PLCL+GT/PCL膜+软骨细胞	20	—	—	软骨细胞生存良好	8周
?	Xia等^[19]	2019	山羊	PCL+耳廓软骨细胞	30	部分区域可见	—	吻合口可见	8周

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