Research progress on animal models of esophageal anastomotic fistula

doi:10.3877/cma.j.issn.2095-8773.2021.02.05

Abstract

Abstract:

Esophageal anastomotic fistula is one of the severe complications of esophagectomy. It is reported that the incidence rate of esophageal anastomotic fistula accounts for 2% to 30% among all postoperative complications of esophagectomy, which can lead to severe infection of the neck, mediastinum, or even retrosternal abscess, and even cause death if not being treated in time. Despite the continuous development of suture techniques and materials, anastomotic fistula remains a unsolved problem. However, at present, there are no stable, reliable and specific animal models, and stable and reliable animal models are important means to clarify the pathogenesis, pathophysiological processes and treatment modalities of esophageal anastomotic fistula. Therefore, we are eager to establish a perfect functional animal model to promote the animal experimental study of esophageal anastomotic fistula and the prevention, treatment and rehabilitation of postoperative esophageal anastomotic fistula. In this paper, the present situation of esophageal anastomotic fistula, the preparation method and evaluation method of animal model of esophageal anastomotic fistula are described and summarized.

Key words: Esophageal Cancer, Esophageal Anastomotic Fistula, Animal Model

Jiawei Zhang, Jiansheng Wang, Guangjian Zhang, Junke Fu, Hangying Qu, Jia Zhang. Research progress on animal models of esophageal anastomotic fistula[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2021, 08(02): 101-107.

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References 54

1	Huang FL, Yu SJ．Esophageal cancer: Risk factors，genetic association，and treatment[J]．Asian J Surg，2018，41(3):210-215.
2	Spechler SJ．Clinical practice．Barrett's Esophagus[J]．N Engl J Med，2002，346(11):836-842.
3	Spechler SJ．Screening and surveillance for complications related to gastroesophageal reflux disease[J]．Am J Med，2001，111(Suppl 8A):130S-136S.
4	Perry KA, Banarjee A, Liu J，et al．Gastric ischemic conditioning increases neovascularization and reduces inflammation and fibrosis during gastroesophageal anastomotic healing[J]．Surg Endosc，2013，27(3):753-760.
5	Huang J, Zhou Y, Wang C，et al．Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal-cardiac cancer[J]．Thorac Cancer，2017，8(6):666-671.
6	Drescher DG, Vogt J, Gabriel M，et al．Model of wound healing for esophagogastric anastomoses in rats[J]．Eur Surg Res，2012，48(4):194-199.
7	Okur H, KüçüKaydin N, Kontaf O，et al．Esophageal anastomosis: an experimental model to study anastomotic healing and the use of lyophilized collagen[J]．Res Exp Med (Berl)，1996，196(5):275-280.
8	薛祥，李春光，阎岩，等．自体干细胞-纤维蛋白胶联合移植治疗食管吻合口瘘的效果分析[J]．中华医学杂志，2015，95(47):3862-3867.
9	杨健．可降解性食管支架治疗食管吻合口瘘的动物实验研究[D]．上海：上海交通大学，2018．
10	Gao Y, Wu RQ, Lv Y，et al．Novel magnetic compression technique for establishment of a canine model of tracheoesophageal fistula[J]．World J Gastroenterol，2019，25(30):4213-4221.
11	Bruns NE, Glenn IC, Craner DR，et al．Magnetic compression anastomosis (magnamosis) in a porcine esophagus: Proof of concept for potential application in esophageal atresia[J]．J Pediatr Surg，2019，54(3):429-433.
12	Nocca D, Aggarwal R, Deneve E，et al．Use of collagen wrap from bovine origin for the management of colic perforation．Preliminary study in a pig model[J]．J Laparoendosc Adv Surg Tech A，2009，19(1):79-83.
13	Lorincz A, Langenburg SE, Knight CG，et al．Robotically assisted esophago-esophagostomy in newborn pigs[J]．J Pediatr Surg，2004，39(9):1386-1389.
14	王洁．食管癌术后吻合口瘘的原因分析及预防[D]．武汉：华中科技大学，2014．
15	牛林鹏．食管癌切除术后吻合口瘘的研究与相关进展[D]．郑州：河北医科大学，2018．
16	陈传贵，于振涛，金庆文，等食管癌术后吻合口瘘的临床特点及危险因素分析[J]．中华外科杂志，2015，53(7):518-521.
17	Escofet X, Manjunath A, Twine C，et al．Prevalence and outcome of esophagogastric anastomotic leak after esophagectomy in a UK regional cancer network[J]．Dis Esophagus，2010，23(2):112-116.
18	袁勇，陈龙奇．食管癌手术中食管胃吻合技术的选择及疗效评价[J]．中华消化外科杂志，2017，16(5):454-458.
19	邵书珍，钱骏．食管癌术后吻合口瘘的影像学诊断进展[J]．局解手术学杂志，2021，30(2):181-184.
20	陆超敬，陈和忠，杨立信．食管贲门癌术后非计划二次手术37例临床分析[J]．中国胸心血管外科临床杂志，2017，24(12):998-1001.
21	Metzger R, Schütze F, Mönig S．Evidence-Based Operative Details in Esophageal Cancer Treatment：Surgical Approach，Lymphadenectomy，Anastomosis[J]．Viszeralmedizin，2015，31(5):337-340.
22	Ryan CE, Paniccia A, Meguid RA et al．Transthoracic Anastomotic Leak After Esophagectomy：Current Trends[J]．Ann Surg Oncol，2017，24(1):281-290.
23	Raymond DP．The esophageal anastomosis: traditional methods to prevent leak[J]．J Gastrointest Surg，2009，13(9):1555-1557.
24	Okamura A, Watanabe M, Imamura Y，et al．Preoperative Glycosylated Hemoglobin Levels Predict Anastomotic Leak After Esophagectomy with Cervical Esophagogastric Anastomosis[J]．World J Surg，2017，41(1):200-207.
25	孙玉鹗．胸外科手术学[M]．北京：人民军医出版社，2004．
26	Di Leo M, Maselli R, Ferrara EC，et al．Endoscopic Management of Benign Esophageal Ruptures and Leaks[J]．Curr Treat Options Gastroenterol，2017，15(2):268-284.
27	Verstegen MHP, Bouwense SAW, van Workum F，et al．Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer：a systematic review[J]．World J Emerg Surg，2019，14:17.
28	徐义军，张文杰．消化道吻合口瘘内镜微创治疗的现状及进展[J]．中国普通外科杂志，2019，28(4):491-497.
29	王艳丽，谢霞，周建云，等．OTSC吻合夹在内镜下治疗食管癌术后吻合口瘘中的应用[J]．局解手术学杂志，2019，28(4):299-302.
30	Willingham FF, Buscaglia JM．Endoscopic Management of Gastrointestinal Leaks and Fistulae[J]．Clin Gastroenterol Hepatol，2015，13(10):1714-1721.
31	Feith M, Gillen S, Schuster T，et al．Healing occurs in most patients that receive endoscopic stents for anastomotic leakage；dislocation remains a problem[J]．Clin Gastroenterol Hepatol，2011，9(3):202-210.
32	Weiland T, Fehlker M, Gottwald T，et al．Performance of the OTSC System in the endoscopic closure of gastrointestinal fistulae--a meta-analysis[J]．Minim Invasive Ther Allied Technol，2012，21(4):249-258.
33	Law R, Wong Kee Song LM, Irani S，et al．Immediate technical and delayed clinical outcome of fistula closure using an over-the-scope clip device[J]．Surg Endosc，2015，29(7):1781-1786.
34	Haito-Chavez Y, Law JK, Kratt T，et al．International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video)[J]．Gastrointest Endosc，2014，80(4):610-622.
35	Watson A, Zuchelli T．Repair of upper-GI fistulas and anastomotic leakage by the use of endoluminal vacuum-assisted closure[J]．VideoGIE，2019，4(1):40-44.
36	Rausa E, Asti E, Aiolfi A，et al．Comparison of endoscopic vacuum therapy versus endoscopic stenting for esophageal leaks: systematic review and meta-analysis[J]．Dis Esophagus，2018，31(11).
37	Mennigen R, Senninger N, Laukoetter MG．Endoscopic vacuum therapy of esophageal anastomotic leakage[J]．Gastrointest Endosc，2015，82(2):397.
38	Youn HC, Kwon SH．Endoscopic Vacuum-Assisted Closure (E-VAC) Treatment in a Patient with Delayed Anastomotic Perforation following a Perforated Gastric Conduit Repair after an Ivor-Lewis Esophagectomy[J]．Ann Thorac Cardiovasc Surg，2016，22(6):363-366.
39	Struyve M, De Vloo C, Van Veer H，et al．Endoscopic vacuum-assisted closure therapy for the treatment of oesophageal anastomotic leaks[J]．Acta Gastroenterol Belg，2019，82(4):529-531.
40	Pines G, Bar I, Elami A，et al．Modified Endoscopic Vacuum Therapy for Nonhealing Esophageal Anastomotic Leak: Technique Description and Review of Literature[J]．J Laparoendosc Adv Surg Tech A，2018，28(1):33-40.
41	Mencio MA, Ontiveros E, Burdick JS，et al．Use of a novel technique to manage gastrointestinal leaks with endoluminal negative pressure: a single institution experience[J]．Surg Endosc，2018，32(7):3349-3356.
42	Virgilio E, Ceci D, Cavallini M．Surgical Endoscopic Vacuum-assisted Closure Therapy (EVAC) in Treating Anastomotic Leakages After Major Resective Surgery of Esophageal and Gastric Cancer[J]．Anticancer Res，2018，38(10):5581-5587.
43	Alanezi K, Urschel JD．Mortality secondary to esophageal anastomotic leak[J]．Ann Thorac Cardiovasc Surg，2004，10(2):71-75.
44	张志宇，颜云鹏．食管癌术后胸内消化道瘘12例治疗分析[J]．临床肿瘤学杂志，2007，12(6):454-455.
45	Crestanello JA, Deschamps C, Cassivi SD，et al．Selective management of intrathoracic anastomotic leak after esophagectomy[J]．J Thorac Cardiovasc Surg，2005，129(2):254-260.
46	Stumpf M, Klinge U, Wilms A，et al．Changes of the extracellular matrix as a risk factor for anastomotic leakage after large bowel surgery[J]．Surgery，2005，137(2):229-234.
47	Enestvedt CK, Thompson SK, Chang EY，et al．Clinical review: Healing in gastrointestinal anastomoses，part II[J]．Microsurgery，2006，26(3):137-143.
48	Fedakar-Senyucel M, Bingol-Kologlu M, Vargun R，et al．The effects of local and sustained release of fibroblast growth factor on wound healing in esophageal anastomoses[J]．J Pediatr Surg，2008，43(2):290-295.
49	Urschel JD, Takita H, Antkowiak JG．The effect of ischemic conditioning on gastric wound healing in the rat: implications for esophageal replacement with stomach[J]．J Cardiovasc Surg (Torino)，1997，38(5):535-538.
50	Schaarschmidt K, Paschertz KW, Stratmann U，et al．Tracheoesophageal anastomosis，continent gastrostomy and oesophagostomy--a new experimental model in minipiglets[J]．Lab Anim，1995，29(4):411-419.
51	杨健，孟礼飞，谢晓，等．新型可降解支架治疗食管吻合口瘘的疗效分析[J]．现代生物医学进展，2018，18(11):2043-2046.
52	Scott RB, Ritter LA, Shada AL et al．Endoluminal Vacuum Therapy for Ivor Lewis Anastomotic Leaks: A Pilot Study in a Swine Model[J]．Clin Transl Sci，2017，10(1):35-41.
53	Palacio D, Marom EM, Correa A，et al．Diagnosing conduit leak after esophagectomy for esophageal cancer by computed tomography leak protocol and standard esophagram: Is old school still the best?[J]．Clin Imaging，2018，51:23-29.
54	Upponi S, Ganeshan A, D'Costa H，et al．Radiological detection of post-oesophagectomy anastomotic leak - a comparison between multidetector CT and fluoroscopy[J]．Br J Radiol，2008，81(967):545-548.

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