To investigate the effect of metformin on the prognosis of resectable non-small cell lung cancer (NSCLC) complicated with type 2 diabetes mellitus.

A retrospective review of 177 patients with NSCLC complicated with type 2 diabetes who were resectable between January 2011 and December 2015 was performed. The prognostic impact of different therapy and the clinicopathologic factors were analyzed.

The overall median survival time and the 1-, 3-, and 5-year overall survival rates were 47.0 months, 87.3%, 54.7% and 22.6%, respectively. The median survival time and 1-, 3- and 5-year survival rates of metformin group were 49.0 months and 93.7%, 67.0%, 32.3%, respectively, while those of non-metformin group were 42.0 months and 85.7%, 53.4%, 18.7%, respectively. Univariate analysis showed that metformin, TNM stage, adjuvant chemotherapy and adjuvant radiotherapy had significant differences in prognosis (P<0.05) . Multivariate analysis showed, metformin and TNM stage were independent factors affecting the prognosis of resectable NSCLC patients with type 2 diabetes mellitus (P<0.05) .

Long-term survival is better in patients with resectable NSCLC with type 2 diabetes mellitus taking metformin.

To analyze the funding of the National Natural Science Foundation of China (NSFC) on the field of lung cancer between 2018 to 2020.

Analysis was performed after searching in the database of NSFC with the keywords of "lung cancer" and "pulmonary malignant tumor" .

A total of 751 projects were funded in the field of lung cancer during the past 3 years. Among them, 348 projects were young programme and 330 were general programme. And there were differences between the two kind of programme on the age, profession and titles and professional qualifications.

Lung cancer was one of focused fields funded by NSFC. The applicants should strengthen themselves to conform such a competitive situation.

To evaluate the value of low-dose spiral CT (LDCT) in early lung cancer screening in asymptomatic healthy patients.

3, 730 cases of asymptomatic healthy patients who underwent physical examination in our hospital from January 2016 to December 2017 were selected, all of whom were examined by LDCT and chest X-ray, and the diagnostic accuracy was compared and analyzed to evaluate the practical value of LDCT in early lung cancer screening.

All subjects successfully completed LDCT scan and chest X-ray screening, and the examination images met the clinical diagnostic criteria. Among the 3 730 patients, 1 112 had LDCT positive lesions, including 2.96% of lung cancer, 8.63% of tuberculosis, 38.31% of nodules, 3.59% of bronchiectasis, 15.82% of emphysema, 10.70% of bullae, 4.13% of inflammation, and 15.82% of others. The pulmonary nodules in 426 cases included 38.26% of inflammatory nodules, 41.31%, of solid nodules and 19.95% of ground glass nodules. Among the 3730 patients, 812 had positive lesions screened by chest X-ray, including 2.95% of lung cancer, 11.20% of tuberculosis, 27.22% of nodules, 3.94% of bronchiectasis, 20.32% of emphysema, 11.94% of bullae, 4.80% of inflammation, and 17.61% of other benign old diseases. The number of positive cases, detection rate and detection accuracy of lung cancer, pulmonary nodules and other diseases in the two groups were compared, showing statistically significant differences(P<0.05), which fully demonstrated that the LDCT group was significantly better than the X-ray chest X-ray screening group, and had good diagnostic value. However, for pulmonary nodules, it is difficult to determine the nature of X-ray chest X-ray screening, only the existence of nodules of sufficient size can be diagnosed, and the size of lesions in other diseases is still the main reason for the low accuracy of X-ray diagnosis.

LDCT has good diagnostic value in early lung cancer screening in large scale physical examination of patients ≥40 years old.

To investigate the advantages of thoracoscopic unidirectional lobectomy plus lymphadenectomy in the resection of stageⅠ/Ⅱ non-small cell lung cancer.

Fifty-eight patients with stageⅠ/Ⅱ non-small cell lung cancer treated by thoracic surgery in Chengdu Sixth People's Hospital from January 2013 to June 2018 were selected for this research. All patients underwent surgical resection: those who received conventional thoracotomy plus lymph node dissection were marked as in the control group (n=29), and those who received thoracoscopic unidirectional lobectomy plus lymph node dissection were marked as in the research group(n=29). The differences of operative index, pain and inflammatory factors between the two groups were statistically analyzed.

The incision length, operation time and hospitalization time of the research group were shorter than those of the control group (t=54.707, t=11.934, t=7.574, all P<0.001), and intraoperative bleeding volume of the research group was less than that of the control group (t=24.746, P<0.001). The use rate of analgesics in the research group was 6.9% compared with 27.6% of the control group (χ²=4.350, P=0.037), and the VAS scores of the researoh group at 12, 24 and 48 hours after operation were lower than those of the control group (t=8.134, t=19.039, t=20.872, all P<0.001); The level of C-reactive protein in research group was lower than that in control group (t=17.307, t=19.405, t=16.112, all P<0.001) on the 1st, 3rd and 7th day after operation.

Complete thoracoscopic one-way lobectomy combined with lymph node dissection has the advantages of minimally invasive in the surgical treatment of stageⅠ/Ⅱ non-small cell lung cancer, which can reduce the pain after operation and reduce the level of inflammation, and is suitable for promotion.

To explore the nursing effect of preoperative special respiratory exercise nursing in elderly patients with lung cancer and its impact on lung function.

A total of 152 elderly patients with lung cancer admitted to our hospital from March 2016 to February 2017 were selected and randomly divided into two group. Beyond routine nursing, patients in the special nursing group were treated by preoperative special respiratory exercise nursing while only routine nursing was applied in the control group. The clinical data of the two groups of elderly patients with lung cancer before and after the intervention of respiratory were recorded and compared, including respiratory function changes, pulmonary function changes and incidence of complications after intervention.

The group with preoperative special respiratory exercise nursing has higher MVV, PaO₂, SaO₂ than the control group (P<0.05), with lower respiratory rate and lower incidence of complication(P<0.05). The respiratory index and other lung function indexes of the special nursing group were higher than those of the control group (P<0.05).

To elderly patients with lung cancer before surgery in clinical nursing, special breathing exercise can significantly reduce the incidence of complications after surgery and improve patients’ respiratory function , lung function, thus respiratory index, is worthy of application and promotion.

Nuclear transcription factor Kappa B (NF-κB) is involved in a variety of signaling pathways, including inducing cell inhibition of apoptosis, promoting cell proliferation, invasion, metastasis, and promoting tumor cell angiogenesis, which are closely related to carcinogenesis. This review is intended to provide an overview of the progress in the study of NF-κB signaling pathways in non-small cell lung cancer and esophageal squamous cell carcinoma of common malignancies in thoracic surgery.