Research progress of donor lung maintenance strategy in lung transplantation

doi:10.3877/cma.j.issn.2095-8773.2022.02.02

Abstract

Abstract:

Lung transplantation was the only effective treatment for a variety of end-stage pulmonary diseases, which could significantly improve patients’ quality of life and overall survival. Donor lung quality was one of the key factors, which could affect complication rate. The marginal lung for transplantation significantly increased the incidence of postoperative complications. Therefore, in face of the current situation of supply lung shortage, we need to improve donor lung quality and utilization by improving the donor lung maintenance strategies and the repair technique for marginal donor lung.

Key words: Lung disease, Lung transplantation, Donor lung, Maintenance strategy

Chunguang Li, Zhigang Li. Research progress of donor lung maintenance strategy in lung transplantation[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2022, 09(02): 75-79.

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References 40

1	Forgie KA，Fialka N，Freed DH，et al．Lung Transplantation, Pulmonary Endothelial Inflammation, and Ex-Situ Lung Perfusion: A Review[J]．Cells，2021，10（6）：1417．
2	毛文君，陈静瑜．中国肺移植面临的困难及对策[J]．中华胸部外科电子杂志，2016，3（1）：1-6．
3	Bardossy AC，Snavely EA，Nazarian E，et al．Donor-derived transmission through lung transplantation of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 carbapenemase during an ongoing healthcare facility outbreak[J]．Transpl Infect Dis，2020，22（2）：e13256．
4	Bunsow E，Los-Arcos I，Martin-Gómez MT，et al．Donor-derived bacterial infections in lung transplant recipients in the era of multidrug resistance[J]．J Infect，2020，80（2）：190-196．
5	Lee KH，Jeong SJ，Kim SY，et al．Effects of Multidrug-resistant Bacteria in Donor Lower Respiratory Tract on Early Posttransplant Pneumonia in Lung Transplant Recipients Without Pretransplant Infection[J]．Transplantation，2020，104（4）：e98-e106．
6	Kulkarni HS，Tsui K，Sunder S，et al．Pseudomonas aeruginosa and acute rejection independently increase the risk of donor-specific antibodies after lung transplantation[J]．Am J Transplant，2020，20（4）：1028-1038．
7	Mojtabaee M，Shahryari S，Sadegh Beigee F．Reasons for Donor Lungs Unsuitability After Radiographic Selection[J]．Exp Clin Transplant，2019，17（Suppl 1）：120-122．
8	Shepherd HM，Gauthier JM，Puri V，et al．Advanced considerations in organ donors[J]．J Thorac Dis，2021，13（11）：6528-6535．
9	Miñambres E，Rodrigo E，Ballesteros MA，et al．Impact of restrictive fluid balance focused to increase lung procurement on renal function after kidney transplantation[J]．Nephrol Dial Transplant，2010，25（7）：2352-2356．
10	Munshi L，Keshavjee S，Cypel M．Donor management and lung preservation for lung transplantation[J]．Lancet Respir Med，2013，1（4）：318-328．
11	Determann RM，Royakkers A，Wolthuis EK，et al．Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial[J]．Crit Care，2010，14（1）：R1．
12	Mascia L，Pasero D，Slutsky AS，et al．Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial[J]．JAMA，2010，304（23）：2620-2627．
13	Powner DJ，Graham R．Airway pressure release ventilation during adult donor care[J]．Prog Transplant，2010，20（3）：269-273．
14	Mehaffey JH，Charles EJ，Sharma AK，et al．Airway pressure release ventilation during ex vivo lung perfusion attenuates injury[J]．J Thorac Cardiovasc Surg，2017，153（1）：197-204．
15	Biswas Roy S，Razia D，Arjuna A，et al. Airway pressure release ventilation for in-vivo donor lung management and lung transplant outcomes[J/CD]．Chin J Thorac Surg（Electronic Edition），2022，9（2）．
16	Sadegh Beigee F，Daryani EN，Shahryari S，et al．Role of Methylprednisolone in the Management of Hemodynamically Unstable Brain-Dead Cases[J]．Exp Clin Transplant，2019，17（Suppl 1）：257-259．
17	Shemie SD，Ross H，Pagliarello J，et al．Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential[J]．CMAJ，2006，174（6）：S13-S32．
18	Van Zanden JE，'t Hart NA，Ottens PJ，et al．Methylprednisolone Treatment in Brain Death-Induced Lung Inflammation-A Dose Comparative Study in Rats[J]．Front Pharmacol，2021，12：587003．
19	Peled Y，Ram E，Klempfner R，et al．Donor thyroid hormone therapy and heart transplantation outcomes: ISHLT transplant registry analysis[J]．J Heart Lung Transplant，2020，39（10）：1070-1078．
20	Peled Y，Lavee J，Kassif Y，et al．Donor thyroid hormone therapy is associated with an increased risk of graft dysfunction after heart transplantation[J]．Clin Transplant，2020，34（7）：e13887．
21	Nagy á，Szécsi B，Eke C，et al．Endocrine Management and Hormone Replacement Therapy in Cardiac Donor Management: A Retrospective Observational Study[J]．Transplant Proc，2021，53（10）：2807-2815．
22	Chen-Yoshikawa TF．Ischemia-Reperfusion Injury in Lung Transplantation[J]．Cells，2021，10（6）：1333．
23	Christie JD，Sager JS，Kimmel SE，et al．Impact of primary graft failure on outcomes following lung transplantation[J]．Chest，2005，127（1）：161-165．
24	Kelly RF，Murar J，Hong Z，et al．Low potassium dextran lung preservation solution reduces reactive oxygen species production[J]．Ann Thorac Surg，2003，75（6）：150-155．
25	Van Raemdonck D．Thoracic organs: current preservation technology and future prospects; part 1: lung[J]．Curr Opin Organ Transplant，2010，15（2）：150-155．
26	Laubach VE，Sharma AK．Mechanisms of lung ischemia-reperfusion injury[J]．Curr Opin Organ Transplant，2016，21（3）：246-252．
27	Talaie T，DiChiacchio L，Prasad NK，et al．Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review[J]．Transplant Direct，2021，7（2）：e652．
28	Ali A，Wang A，Ribeiro RVP，et al．Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function[J]．Sci Transl Med，2021，13（611）：eabf7601．
29	Steen S，Sjöberg T，Pierre L，et al．Transplantation of lungs from a non-heart-beating donor[J]．Lancet，2001，357（9259）：825-829．
30	Cypel M，Yeung JC，Liu M，et al．Normothermic ex vivo lung perfusion in clinical lung transplantation[J]．N Engl J Med，2011，364（15）：1431-1440．
31	Yeung JC，Krueger T，Yasufuku K，et al．Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study[J]．Lancet Respir Med，2017，5（2）：119-124．
32	Leiva-Juárez MM，Urso A，Arango Tomás E，et al．Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: Results from a multicentric study[J]．J Heart Lung Transplant，2020，39（9）：954-961．
33	Charles EJ，Mehaffey JH，Sharma AK，et al．Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism[J]．J Thorac Cardiovasc Surg，2017，154（5）：1811-1820．
34	Luc JG，Bozso SJ，Freed DH，et al．Successful repair of donation after circulatory death lungs with large pulmonary embolus using the lung organ care system for ex vivo thrombolysis and subsequent clinical transplantation[J]．Transplantation，2015，99（1）：e1-e2．
35	Machuca TN，Cypel M，Bonato R，et al．Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model[J]．Hum Gene Ther，2017，28（9）：757-765．
36	Nykänen AI，Mariscal A，Duong A，et al．Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment[J]．Mol Ther Methods Clin Dev，2021，23：184-197．
37	Nakajima D，Watanabe Y，Ohsumi A，et al．Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation[J]．J Heart Lung Transplant，2019，38（11）：1214-1223．
38	Nakajima D，Cypel M，Bonato R，et al．Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs[J]．Am J Transplant，2016，16（4）：1229-1237．
39	Nakajima D，Liu M，Ohsumi A，et al．Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury[J]．J Heart Lung Transplant，2017，36（5）：577-585．
40	Hijiya K，Chen-Yoshikawa TF，Kondo T，et al．Bronchodilator Inhalation During Ex Vivo Lung Perfusion Improves Posttransplant Graft Function After Warm Ischemia[J]．Ann Thorac Surg，2017，103（2）：447-453．

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