Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Thoracic Surgery(Electronic Edition) ›› 2024, Vol. 11 ›› Issue (03): 193-200. doi: 10.3877/cma.j.issn.2095-8773.2024.03.08

• Experience • Previous Articles    

Clinical application of lung autotransplantation in thoracic malignancies

Zijian Li1, Rui Wang1, Yunpeng Zhong1, Dixuan Zhang1, Yunjuan Liang1, Chao Yang1, Jianxing He1, Shuben Li1,()   

  1. 1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Thoracic Surgery, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  • Received:2024-06-11 Revised:2024-08-02 Accepted:2024-08-08 Online:2024-08-28 Published:2024-09-20
  • Contact: Shuben Li
  • About author:

    *Co-first authors.

Abstract:

Objective

The lung autotransplantation technique is one of the alternatives to pneumonectomy for thoracic malignancies, including locally advanced central lung cancer and pulmonary artery sarcoma. This study summarizes the experience and application of lung autotransplantation techniques in treating thoracic malignancies at our center.

Methods

Five patients (3 males and 2 females) of thoracic malignancies who underwent lung autotransplantation at the First Affiliated Hospital of Guangzhou Medical University between July 2019 and March 2024 were enrolled. Surgical approaches, reconstruction methods, perioperative conditions (operating time, intraoperative blood loss, postoperative respiratory support duration, postoperative ICU stay, postoperative drainage tube placement duration, postoperative hospital stay) , and follow-up results were retrospectively reviewed.

Results

All five cases successfully received radical resection of thoracic malignancies, including one case of lung autotransplantation of the right lower lobe, one case of the left lower lobe basal segment, and three cases of the right lower lobe basal segment. In situ lung autotransplantation was performed in one case, while the remaining four cases underwent the procedure through ex situ method. The operating time was 460 (45) minutes, the postoperative respiratory support duration was 4 (2) days, the postoperative ICU stay was 4 (2) days, and the postoperative hospital stay was 11 (5) days. There were no perioperative deaths and severe complications including pulmonary embolism and anastomotic leakage. Follow-up revealed one case of pathological right tracheal lymph node metastasis at 40 weeks postoperatively; the other four patients showed no recurrence or metastasis. The overall recurrence-free survival was 13.9 (47.9) months.

Conclusions

Lung autotransplantation is a safe and feasible approach for clinical application of locally advanced central non-small cell lung cancer, pulmonary artery sarcoma, and other thoracic malignancies, which is worthy of further promotion.

Key words: Lung autotransplantation, Non-small cell lung cancer, Pulmonary artery sarcoma, Safety

京ICP 备07035254号-28
Copyright © Chinese Journal of Thoracic Surgery(Electronic Edition), All Rights Reserved.
Tel: 021-61675196 Fax: (010)85158381 E-mail: editor@thecjts.cn
Powered by Beijing Magtech Co. Ltd