Abstract:
Objective To investigate the effect of thoracotomy on pulmonary surfactant(PS) in moderate high altitude localities.
Methods Twenty-one patients with esophageal carcinoma undergoing thoracotomy on the left between September 2013 and April 2015 in Department of Thoracic Surgery in Qinhai Provincial People’s Hospital were enrolled. Bilateral broneho-alveolar lavage was carried out before and after operation. The indicators including saturated phosphati-dylcholine (SatPC), total protein(TP) and total phospholipid(TPL) in broneho-alveolar lavage fluid (BALF) were measured. The corresponding indicators in the right side were served as controls, and SatPC/TPL and SatPC/TP as indicators of activity of PS in BALF.
Results Before operation, the values of SatPC/TPL in BALF were (48.75±14.39)% and (48.76±12.90)% in the left side and right side, respectively, and those were (10.88±2.24)% and (11.78±2.24)%, respectively for SatPC/TP in BALF, with no significant difference in these two indicators between two sides(t=-0.0024, P>0.05; t=-1.3019, P>0.05). After operation, the value of SatPC/TPL in BALF in the left side was significantly smaller than that in the right side [(26.15±9.81)% vs (47.62±12.58)%, t=6.1674, P<0.01], and the value of SatPC/TP in BALF in the left side was also significantly smaller than that in the right side [(5.34±2.54)% vs (10.15±2.28)%, t=6.4579, P<0.01]. The value of SatPC/TPL in BALF after operation was significantly smaller than that before operation in the left side[ (26.15±9.81)% vs (48.75±14.39)%, t=5.9467, P<0.01], and the value of SatPC/TP in BALF after operation was also significantly smaller than that before operation in the left side[ (5.34±2.54)% vs (10.88±2.24)%, t=7.4964, P<0.01]. The value of SatPC/TPL in BALF after operation was not significantly different from that before operation in the right side[ (47.62±12.58)% vs (48.76±12.90)%, t=0.2889, P>0.05], and the value of SatPC/TP in BALF after operation was also not significantly smaller than that before operation in right left side [ (10.15±2.28)% vs (11.78±2.24)%, t=2.3370, P>0.05].
Conclusion In the moderate high altitude localities, thoracotomy may induce lung injury and decrease the activity of PS in the operation side, while it may not cause injury in the non-operation side.
Key words:
Moderate high altitude localities,
Thoracotomy,
Broneho-alveolar lavage,
Pulmonary surfactant
Gang Liu, Xiu-ling Wei, Linjiang Yang, Guowei Liu, Yan Shao. Effect of thoracotomy on pulmonary surfactant in moderate high altitude localities[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2015, 02(02): 119-122.