Expression of PEBP4 protein and its relationship with differentiation and metastasis of squamous cell carcinoma of lung

doi:10.3877/cma.j.issn.2095-8773.2016.03.10

Abstract

Abstract:

Lung cancer, especiallysquamous cell carcinoma of lung, is a diseasewhich posesserious threat to human beings. Therefore, more accurate and effective molecular markersshould befoundin order to provide a scientific basis forthe early detection, prognosisprediction and targeted therapyof lung cancer. Phosphatidylethanolamine-binding protein 4 (PEBP4) belongs to the phosphatidylethanolamine binding protein family members, whichnot onlyinhibitsthe MAPK signaling pathway, but also participatesin the inhibition of JNK pathway andpromotion of AKTactivation. It has been recently reported thattheoverexpression of PEBP4 protein is relatedtothe development and metastasis of a variety of tumors. This review discusses the relationship between the expression of PEBP4 and differentiation and metastasis of squamous cell carcinoma of lung.

Key words: Lung cancer, Differentiation and metastasis, PEBP4, Signaling pathway

Guiping Yu. Expression of PEBP4 protein and its relationship with differentiation and metastasis of squamous cell carcinoma of lung[J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2016, 03(03): 177-181.

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References 38

[1]	GowerAC,SteilingK,BrothersJF, et al. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease[J]. Proc Am Thorac Soc, 2011, 8(2): 173-179.
[2]	HassaneinM,RahmanJS,ChaurandP, et al. Advances in Proteomic Strategies toward the Early Detection of Lung Cancer[J]. Proc Am Thorac Soc, 2011. 8(2): 183-188.
[3]	SundarIK,MullapudiN,YaoH, et al. Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics[J]. Curr Opin Pulm Med, 2011, 17(4)：279-85.
[4]	GarciaM,JemalA,WardEM. Global cancer facts & figures 2007[R]. Atlanta, GA: Amercian Cancer Society, 2007.
[5]	杨玲，李连弟，陈育德. 中国肺癌死亡趋势分析及发病、死亡的估计与预测[J]. 中国肺癌杂志，2005, 8(4): 274-278.
[6]	GiangrecoA,GrootKR,JanesSM. Lung cancer and lung stem cells: strange bedfellows? [J] Am J Respir Crit Care Med, 2007，175(6): 547-553.
[7]	Al-MullaF,BitarMS,Al-MaghrebiM, et al. Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3beta[J]. Cancer Res, 2011. 71(4): 1334-1343.
[8]	GarciaR,GrindlayJ,RathO, et al. Regulation of human myoblast differentiation by PEBP4[J]. EMBO Rep, 2009, 10(3): 278-284.
[9]	KikuchiR,KawahigashiH,AndoT, et al. Molecular and functional characterization of PEBP genes in barley reveal the diversification of their roles in flowering[J]. Plant Physiol, 2009, 149(3): 1341-1353.
[10]	ZaravinosA,ChatziioannouM,LambrouGI, et al. Implication of RAF and RKIP genes in urinary bladder cancer[J]. Pathol Oncol Res, 2011，17(2): 181-190.
[11]	LiuH,QiuJ,LiN, et al. Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src[J]. J Biol Chem, 2010，285(29): 21934-21942.
[12]	YeungK,JanoschP,McFerranB, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein[J]. Mol Cell Biol, 2000，20(9): 3079-3085.
[13]	LiH,WangX,LiN, et al. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways[J]. J Biol Chem, 2007, 282(7): 4943-4950.
[14]	QianY,CorumL,MengQ, et al. PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration[J]. Am J Physiol Cell Physiol, 2004，286(1): C153-C163.
[15]	CaoC,ManganasC,AngSC，et al. Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients[J]. Interact CardioVasc Thorac Surg，2013, 16(3)：244-249.
[16]	SanghaR,ButtsC．L-BLP25: a peptide vaccine strategy in non small cell lung cancer[J]．Clin Cancer Res. 2007, 13(15 Pt 2)：s4652-s4654.
[17]	ChyanW,ZhangDY,LippardSJ, et al. Reaction-based fluorescent sensor for investigating mobile Zn2＋ in mitochondria of healthy versus cancerous prostate cells[J]. Proc Natl Acad Sci U S A，2014, 111(1)：143-148.
[18]	ChoY,TurnerND,DavidsonLA, et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation[J]. Exp Biol Med (Maywood)，2014, 239(3)：302-310.
[19]	WangWY,AlbertCJ,FordDA. Alpha-chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress[J]. Arterioscler Thromb Vasc Biol，2014, 34(3)：526-532.
[20]	LeePJ,RudenkoD,KuliszewskiMA, et al. Survivin gene therapy attenuates left ventricular systolic dysfunction in doxorubicin cardiomyopathy by reducing apoptosis and fibrosis[J]. Cardiovasc Res, 2014, 101(3)：423-433.
[21]	GattiL,CossaG,TinelliS, et al. Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment[J]. J Pharmacol Exp Ther, 2014, 348(3)：360-371.
[22]	ZhaoX,ZhangY,LiX，et al. Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats[J]. Acta Biochim Biophys Sin (Shanghai)，2014, 46(4)：318-329.
[23]	DalalS,ZhaQ,DanielsCR, et al. Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress[J]. Am J Physiol Heart Circ Physiol, 2014, 306(8)：H1182-H1191.
[24]	SchwarzerC1,RavishankarB,PatanwalaM, et al. Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia[J]. Am J Physiol Cell Physiol，2014, 306(9)：C844-C855.
[25]	WeinbergE,MaymonT,WeinrebM. AGEs induce caspase-mediated apoptosis of rat BMSCs via TNFα production and oxidative stress[J]. J Mol Endocrinol，2014, 52(1)：67-76.
[26]	WangQ,ZhangM,DingY, et al. Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo[J]. Circ Res，2014, 114(3)：480-492.
[27]	RaoAJ,JohnstonTR,HarrisAH, et al. Inhibition of chondrocyte and synovial cell death after exposure to commonly used anesthetics: chondrocyte apoptosis after anesthetics[J]. Am J Sports Med，2014, 42(1)：50-58.
[28]	ChenYH,LiZH,TanY, et al. Prenatal exposure to decabrominated diphenyl ether impairs learning ability by altering neural stem cell viability, apoptosis, and differentiation in rat hippocampus[J]. Hum Exp Toxicol, 2014 Feb 24. [Epub ahead of print]
[29]	RoscioliE,HamonR,RuffinRE, et al. Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines[J]. Physiol Rep，2013, 1(5)：e00123.
[30]	LvJ,ZhangP,ZhangY, et al. Maternal high-salt intake during pregnancy reprogrammed renin-angiotensin system-mediated cardiomyocyte apoptosis in the adult offspring heart[J]. Reprod Sci，2014, 21(1)：52-62.
[31]	KroonAA,DelriccioV,TseuI, et al. Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway[J]. Am J Physiol Lung Cell Mol Physiol, 2013, 305(11)：L795-L804.
[32]	KangSS,HaSJ,KimES, et al. Effect of nerve growth factor on the in vitro induction of apoptosis of human conjunctival epithelial cells by hyperosmolar stress[J]. Invest Ophthalmol Vis Sci, 2014, 55(1)：535-541.
[33]	HecquetCM,ZhangM,MittalM, et al. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis[J]. Circ Res, 2014, 114(3)：469-479.
[34]	SunC,ZhangYY,TangCL, et al.Chemokine CCL28 induces apoptosis of decidual stromal cells via binding CCR3/CCR10 in human spontaneous abortion[J]. Mol Hum Reprod，2013, 19(10)：676-686.
[35]	ZiaeiA,SchmedtT,ChenY, et al. Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment[J]. Invest Ophthalmol Vis Sci, 2013, 54(10)：6724-6734.
[36]	XiaoZ,KoHL,GohEH, et al. hnRNP K suppresses apoptosis independent of p53 status by maintaining high levels of endogenous caspase inhibitors[J]. Carcinogenesis，2013, 34(7)：1458-1467.
[37]	HuN,DongM,RenJ．Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis[J]. Am J Physiol Regul Integr Comp Physiol，2014, 306(10)：R761-R71.
[38]	XuG1,DuanZ,ChenG, et al. Role of mitogen-activated protein kinase cascades in 2，3，7，8-tetrachlorodibenzo-p-dioxin-induced apoptosis in neuronal pheochromocytoma cells[J]. Hum Exp Toxicol，2013, 32(12)：1278-1291.

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